IGFBP4

IGFBP4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1WQJ, 2DSP, 2DSQ, 2DSR
Dynodwyr
Cyfenwau	IGFBP4, BP-4, HT29-IGFBP, IBP4, IGFBP-4, insulin like growth factor binding protein 4
Dynodwyr allanol	OMIM: 146733 HomoloGene: 1192 GeneCards: IGFBP4
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• insulin-like growth factor I binding; • insulin-like growth factor II binding; • signaling receptor binding; • insulin-like growth factor binding; • growth factor binding; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• extracellular region; • extracellular space; • endoplasmic reticulum lumen;
Prosesau biolegol	• skeletal system development; • regulation of growth; • DNA metabolic process; • regulation of insulin-like growth factor receptor signaling pathway; • regulation of glucose metabolic process; • cell population proliferation; • inflammatory response; • positive regulation of insulin-like growth factor receptor signaling pathway; • type B pancreatic cell proliferation; • negative regulation of canonical Wnt signaling pathway; • regulation of cell growth; • GO:0072468 signal transduction; • positive regulation of MAPK cascade; • post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologau
	3487
	n/a
	ENSG00000141753
	n/a
	P22692
	n/a
	NM_001552
	n/a
	NP_001543
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IGFBP4 yw IGFBP4 a elwir hefyd yn Insulin like growth factor binding protein 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q21.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IGFBP4.

BP-4
IBP4
IGFBP-4
HT29-IGFBP

Llyfryddiaeth

"Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells. ". J Immunol. 2017. PMID 28724578.
"Insulin-Like Growth Factor Binding Protein-4 as a Marker of Chronic Lupus Nephritis. ". PLoS One. 2016. PMID 27019456.
"IGFBP-4 Fragments as Markers of Cardiovascular Mortality in Type 1 Diabetes Patients With and Without Nephropathy. ". J Clin Endocrinol Metab. 2015. PMID 26046968.
"PAPP-A and IGFBP-4 fragment levels in patients with ST-elevation myocardial infarction treated with heparin and PCI. ". Clin Biochem. 2015. PMID 25489725.
"IBP regulates epithelial-to-mesenchymal transition and the motility of breast cancer cells via Rac1, RhoA and Cdc42 signaling pathways.". Oncogene. 2014. PMID 23975422.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] IGFBP4 - Cronfa NCBI

[1]

[2]