IGFBP5

IGFBP5
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1BOE, 1H59
Dynodwyr
Cyfenwau	IGFBP5, IBP5, insulin like growth factor binding protein 5
Dynodwyr allanol	OMIM: 146734 HomoloGene: 56489 GeneCards: IGFBP5
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• fibronectin binding; • insulin-like growth factor binding; • growth factor binding; • insulin-like growth factor I binding; • insulin-like growth factor II binding; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• insulin-like growth factor ternary complex; • extracellular region; • insulin-like growth factor binding protein complex; • endoplasmic reticulum lumen; • extracellular space;
Prosesau biolegol	• negative regulation of smooth muscle cell proliferation; • negative regulation of translation; • positive regulation of protein kinase B signaling; • GO:0007243 intracellular signal transduction; • negative regulation of growth; • glucose homeostasis; • female pregnancy; • GO:1904579 cellular response to organic cyclic compound; • negative regulation of smooth muscle cell migration; • negative regulation of osteoblast differentiation; • regulation of glucose metabolic process; • negative regulation of cell migration; • positive regulation of insulin-like growth factor receptor signaling pathway; • regulation of cell growth; • osteoblast differentiation; • response to growth hormone; • glucose metabolic process; • negative regulation of insulin-like growth factor receptor signaling pathway; • hair follicle morphogenesis; • regulation of growth; • negative regulation of muscle tissue development; • striated muscle cell differentiation; • lung alveolus development; • negative regulation of skeletal muscle hypertrophy; • type B pancreatic cell proliferation; • cellular response to cAMP; • GO:0072468 signal transduction; • mammary gland involution; • GO:0010260 heneiddio; • post-translational protein modification; • positive regulation of vascular associated smooth muscle cell proliferation; • positive regulation of vascular associated smooth muscle cell migration; • regulation of insulin-like growth factor receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	3488
	n/a
	ENSG00000115461
	n/a
	P24593
	n/a
	NM_000599
	n/a
	NP_000590
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IGFBP5 yw IGFBP5 a elwir hefyd yn Insulin like growth factor binding protein 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q35.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IGFBP5.

IBP5

Llyfryddiaeth

"Correlation between the DNA methylation and gene expression of IGFBP5 in breast cancer. ". Breast Dis. 2016. PMID 27612043.
"IGFBP5 enhances osteogenic differentiation potential of periodontal ligament stem cells and Wharton's jelly umbilical cord stem cells, via the JNK and MEK/Erk signalling pathways. ". Cell Prolif. 2016. PMID 27484838.
"IGFBP-5 Promotes Fibrosis Independently of Its Translocation to the Nucleus and Its Interaction with Nucleolin and IGF. ". PLoS One. 2015. PMID 26103640.
"Insulin-like growth factor binding protein 5 (IGFBP5) functions as a tumor suppressor in human melanoma cells. ". Oncotarget. 2015. PMID 26010068.
"Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.". Nat Commun. 2014. PMID 25248036.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] IGFBP5 - Cronfa NCBI

[1]

[2]