IKBKB |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/7/70/Protein_IKBKB_PDB_3BRT.png/250px-Protein_IKBKB_PDB_3BRT.png) |
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Dynodwyr |
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Cyfenwau | IKBKB, IKK-beta, IKK2, IKKB, IMD15, NFKBIKB, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, inhibitor of nuclear factor kappa B kinase subunit beta, IMD15A, IMD15B |
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Dynodwyr allanol | OMIM: 603258 HomoloGene: 7782 GeneCards: IKBKB |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Protein sy'n cael ei godio yn y corff dynol gan y genyn IKBKB yw IKBKB a elwir hefyd yn Inhibitor of nuclear factor kappa B kinase subunit beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 8, band 8p11.21.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IKBKB.
- IKK2
- IKKB
- IMD15
- NFKBIKB
- IKK-beta
- "Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition. ". Redox Biol. 2017. PMID 28107677.
- "Inhibition of IKKβ by celastrol and its analogues - an in silico and in vitro approach. ". Pharm Biol. 2017. PMID 27931154.
- "IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. ". Genes Dev. 2016. PMID 27585591.
- "IκB-Kinase-epsilon (IKKε) over-expression promotes the growth of prostate cancer through the C/EBP-β dependent activation of IL-6 gene expression. ". Oncotarget. 2017. PMID 27577074.
- "Cis- and Trans-gnetin H from Paeonia suffruticosa suppress inhibitor kappa B kinase phosphorylation in LPS-stimulated human THP-1 cells.". J Ethnopharmacol. 2016. PMID 27196294.