IL10

IL10
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1ILK, 1INR, 1J7V, 1LK3, 1Y6K, 2ILK, 2H24
Dynodwyr
Cyfenwau	IL10, CSIF, GVHDS, IL-10, IL10A, TGIF, interleukin 10
Dynodwyr allanol	OMIM: 124092 HomoloGene: 478 GeneCards: IL10
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • growth factor activity; • cytokine activity; • interleukin-10 receptor binding; • protein dimerization activity;
Cydrannau o'r gell	• extracellular region; • extracellular space;
Prosesau biolegol	• negative regulation of chronic inflammatory response to antigenic stimulus; • positive regulation of MHC class II biosynthetic process; • negative regulation of endothelial cell apoptotic process; • hemopoiesis; • negative regulation of interferon-gamma production; • regulation of sensory perception of pain; • positive regulation of B cell apoptotic process; • negative regulation of chemokine (C-C motif) ligand 5 production; • response to inactivity; • negative regulation of cytokine activity; • negative regulation of interleukin-1 production; • cellular response to hepatocyte growth factor stimulus; • cellular response to estradiol stimulus; • negative regulation of interleukin-6 production; • GO:0010260 heneiddio; • positive regulation of DNA-binding transcription factor activity; • negative regulation of apoptotic process; • GO:0002719 negative regulation of cytokine production involved in immune response; • response to glucocorticoid; • cytoplasmic sequestering of NF-kappaB; • negative regulation of interleukin-18 production; • negative regulation of MHC class II biosynthetic process; • response to activity; • response to organic substance; • response to carbon monoxide; • leukocyte chemotaxis; • type 2 immune response; • negative regulation of myeloid dendritic cell activation; • response to insulin; • negative regulation of interleukin-8 production; • response to lipopolysaccharide; • B cell proliferation; • negative regulation of T cell proliferation; • negative regulation of nitric oxide biosynthetic process; • branching involved in labyrinthine layer morphogenesis; • defense response to bacterium; • regulation of complement-dependent cytotoxicity; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • regulation of gene expression; • B cell differentiation; • regulation of isotype switching; • negative regulation of tumor necrosis factor production; • negative regulation of membrane protein ectodomain proteolysis; • inflammatory response; • cellular response to lipopolysaccharide; • negative regulation of B cell proliferation; • negative regulation of inflammatory response; • GO:0032697 negative regulation of cytokine production; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • negative regulation of interleukin-12 production; • defense response to protozoan; • negative regulation of sensory perception of pain; • positive regulation of macrophage activation; • liver regeneration; • GO:1904739 regulation of synapse organization; • positive regulation of endothelial cell proliferation; • negative regulation of cell population proliferation; • negative regulation of heterotypic cell-cell adhesion; • positive regulation of heterotypic cell-cell adhesion; • positive regulation of cell cycle; • negative regulation of mitotic cell cycle; • endothelial cell apoptotic process; • regulation of response to wounding; • negative regulation of vascular associated smooth muscle cell proliferation; • positive regulation of vascular associated smooth muscle cell proliferation; • interleukin-12-mediated signaling pathway; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • negative regulation of autophagy; • cytokine-mediated signaling pathway; • positive regulation of receptor signaling pathway via JAK-STAT; • positive regulation of pri-miRNA transcription by RNA polymerase II; • negative regulation of hydrogen peroxide-induced neuron death; • positive regulation of sprouting angiogenesis;
	Sources:Amigo / QuickGO
Orthologau
	3586
	n/a
	ENSG00000136634
	n/a
	P22301
	n/a
	NM_000572
	n/a
	NP_000563
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IL10 yw IL10 a elwir hefyd yn Interleukin 10 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q32.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL10.

CSIF
TGIF
GVHDS
IL-10
IL10A

Llyfryddiaeth

"Association of interleukin-10 gene single nucleotide polymorphisms with susceptibility to systemic lupus erythematosus in a Chinese population. ". Gene. 2018. PMID 29199038.
"Association of Systemic Inflammatory and Anti-inflammatory Responses with Adverse Outcomes in Acute Pancreatitis: Preliminary Results of an Ongoing Study. ". Dig Dis Sci. 2017. PMID 29080144.
"Interleukin-10-regulated tumour tolerance in non-small cell lung cancer. ". Br J Cancer. 2017. PMID 29016555.
"IL10 Release upon PD-1 Blockade Sustains Immunosuppression in Ovarian Cancer. ". Cancer Res. 2017. PMID 28993412.
"Alzheimer's disease and cytokine IL-10 gene polymorphisms: is there an association?". Arq Neuropsiquiatr. 2017. PMID 28977146.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] IL10 - Cronfa NCBI

[1]

[2]