IL18

IL18
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1J0S, 2VXT, 3F62, 4EEE, 4EKX, 4HJJ, 3WO2, 3WO3, 3WO4, 4R6U, 4XFS, 4XFT, 4XFU
Dynodwyr
Cyfenwau	IL18, IGIF, IL-18, IL-1g, IL1F4, interleukin 18
Dynodwyr allanol	OMIM: 600953 HomoloGene: 1200 GeneCards: IL18
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • cytokine activity; • interleukin-18 receptor binding;
Cydrannau o'r gell	• cytosol; • extracellular region; • extracellular space;
Prosesau biolegol	• positive regulation of inflammatory response; • cell-cell signaling; • GO:1904579 cellular response to organic cyclic compound; • type 2 immune response; • MAPK cascade; • positive regulation of natural killer cell proliferation; • Cwsg; • regulation of cell adhesion; • positive regulation of NK T cell proliferation; • positive regulation of granulocyte macrophage colony-stimulating factor production; • positive regulation of tissue remodeling; • angiogenesis; • T-helper 1 type immune response; • positive regulation of interleukin-17 production; • inflammatory response; • lipopolysaccharide-mediated signaling pathway; • positive regulation of activated T cell proliferation; • positive regulation of protein kinase B signaling; • positive regulation of phosphatidylinositol 3-kinase signaling; • positive regulation of smooth muscle cell proliferation; • activation of protein kinase B activity; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of tyrosine phosphorylation of STAT protein; • GO:1901313 positive regulation of gene expression; • positive regulation of macrophage derived foam cell differentiation; • natural killer cell activation; • positive regulation of interferon-gamma production; • cholesterol homeostasis; • positive regulation of T-helper 2 cell differentiation; • negative regulation of myoblast differentiation; • triglyceride homeostasis; • cell population proliferation; • regulation of signaling receptor activity; • interleukin-6 production; • T-helper 1 cell cytokine production; • neutrophil activation; • natural killer cell mediated cytotoxicity; • cytokine-mediated signaling pathway; • interleukin-18-mediated signaling pathway; • positive regulation of NIK/NF-kappaB signaling; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • positive regulation of NF-kappaB transcription factor activity; • positive regulation of T-helper 1 cell cytokine production; • positive regulation of cold-induced thermogenesis; • positive regulation of neuroinflammatory response; • GO:0072468 signal transduction;
	Sources:Amigo / QuickGO
Orthologau
	3606
	n/a
	ENSG00000150782
	n/a
	Q14116
	n/a
	NM_001243211; NM_001562; NM_001386420
	n/a
	NP_001230140; NP_001553; NP_001230140.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IL18 yw IL18 a elwir hefyd yn Interleukin 18 ac Interleukin 18 (Interferon-gamma-inducing factor), isoform CRA_a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q23.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL18.

IGIF
IL-18
IL-1g
IL1F4

Llyfryddiaeth

"Alteration of -656(G/T) and -607(C/A) polymorphisms in interleukin-18 (IL-18) gene in house dust mite-sensitive allergic rhinitis patients in Thailand. ". Genet Mol Res. 2017. PMID 28692122.
"Genetic variants of interleukin-18 are associated with reduced risk of atrial fibrillation in a population from Northeast China. ". Gene. 2017. PMID 28526653.
"Interleukin-18 activates VÎ³9VÎ´2+ T cells from HIV-positive individuals: recovering the response to phosphoantigen. ". Immunology. 2017. PMID 28342224.
"Genetic basis for variation in plasma IL-18 levels in persons with chronic hepatitis C virus and human immunodeficiency virus-1 infections. ". Genes Immun. 2017. PMID 28300059.
"Assessment of IL-18 Serum Level and Its Promoter Polymorphisms in the Saudi Coronary Artery Disease (CAD) Patients.". J Cell Biochem. 2017. PMID 28059484.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] IL18 - Cronfa NCBI

[1]

[2]