IL2

IL2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1IRL, 1M47, 1M48, 1M49, 1M4A, 1M4B, 1M4C, 1NBP, 1PW6, 1PY2, 1QVN, 1Z92, 2B5I, 2ERJ, 3QAZ, 3QB1, 3INK, 4NEJ, 4NEM
Dynodwyr
Cyfenwau	IL2, IL-2, TCGF, lymphokine, interleukin 2
Dynodwyr allanol	OMIM: 147680 HomoloGene: 488 GeneCards: IL2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• cytokine activity; • interleukin-2 receptor binding; • glycosphingolipid binding; • kinase activator activity; • growth factor activity; • kappa-type opioid receptor binding; • carbohydrate binding; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• extracellular region; • intracellular anatomical structure; • extracellular space;
Prosesau biolegol	• positive regulation of T cell differentiation; • GO:0033128 negative regulation of protein phosphorylation; • G protein-coupled receptor signaling pathway; • positive regulation of protein phosphorylation; • positive regulation of inflammatory response; • adaptive immune response; • negative regulation of heart contraction; • immune system process; • positive regulation of cytosolic calcium ion concentration; • positive regulation of regulatory T cell differentiation; • cell-cell signaling; • positive regulation of interferon-gamma production; • natural killer cell activation; • negative regulation of apoptotic process; • positive regulation of dendritic spine development; • negative regulation of lymphocyte proliferation; • MAPK cascade; • regulation of T cell homeostatic proliferation; • T cell differentiation; • positive regulation of cell growth; • protein kinase C-activating G protein-coupled receptor signaling pathway; • cell adhesion; • positive regulation of B cell proliferation; • positive regulation of tissue remodeling; • positive regulation of T cell proliferation; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • positive regulation of cell population proliferation; • extrinsic apoptotic signaling pathway in absence of ligand; • negative regulation of B cell apoptotic process; • positive regulation of isotype switching to IgG isotypes; • positive regulation of interleukin-17 production; • response to ethanol; • negative regulation of inflammatory response; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of activated T cell proliferation; • negative regulation of T-helper 17 cell differentiation; • leukocyte activation involved in immune response; • positive regulation of tyrosine phosphorylation of STAT protein; • regulation of regulatory T cell differentiation; • regulation of signaling receptor activity; • cytokine-mediated signaling pathway; • interleukin-2-mediated signaling pathway; • positive regulation of kinase activity;
	Sources:Amigo / QuickGO
Orthologau
	3558
	n/a
	ENSG00000109471
	n/a
	P60568
	n/a
	NM_000586
	n/a
	NP_000577
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IL2 yw IL2 a elwir hefyd yn Interleukin 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q27.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL2.

IL-2
TCGF
lymphokine

Llyfryddiaeth

"Ontak-like human IL-2 fusion toxin. ". J Immunol Methods. 2017. PMID 28551309.
"Anticancer agent pristimerin inhibits IL-2 induced activation of T lymphocytes. ". J Exp Ther Oncol. 2016. PMID 28471123.
"Lymphocytes incubated in the presence of IL-2 lose the capacity for chemotaxis but acquire antitumor activity. ". Dokl Biol Sci. 2017. PMID 28429264.
"Adoptive immunotherapy with interleukin-2 & induced killer cells in non-small cell lung cancer: A systematic review & meta-analysis. ". Indian J Med Res. 2016. PMID 27748271.
"IL-2 and polyoma BK virus infection; A systematic review article.". Cytokine. 2016. PMID 27718431.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] IL2 - Cronfa NCBI

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[2]