IL2RA

IL2RA
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1Z92, 2B5I, 2ERJ, 3IU3, 3NFP
Dynodwyr
Cyfenwau	IL2RA, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha
Dynodwyr allanol	OMIM: 147730 HomoloGene: 360 GeneCards: IL2RA
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• interleukin-2 receptor activity; • interleukin-2 binding; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• integral component of membrane; • bilen; • Cellbilen; • cell surface; • external side of plasma membrane; • intracellular anatomical structure; • interleukin-2 receptor complex;
Prosesau biolegol	• Notch signaling pathway; • positive regulation of T cell differentiation; • regulation of T cell tolerance induction; • inflammatory response to antigenic stimulus; • negative regulation of defense response to virus; • immune system process; • activation-induced cell death of T cells; • negative regulation of lymphocyte proliferation; • MAPK cascade; • T cell homeostasis; • regulation of T cell homeostatic proliferation; • cell surface receptor signaling pathway; • negative regulation of T cell proliferation; • negative regulation of immune response; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • positive regulation of T cell proliferation; • cell population proliferation; • inflammatory response; • negative regulation of inflammatory response; • positive regulation of activated T cell proliferation; • GO:0097285 apoptotic process; • regulation of regulatory T cell differentiation; • cytokine-mediated signaling pathway; • interleukin-2-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	3559
	n/a
	ENSG00000134460
	n/a
	P01589
	n/a
	NM_000417; NM_001308242; NM_001308243
	n/a
	NP_000408; NP_001295171; NP_001295172
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IL2RA yw IL2RA a elwir hefyd yn Interleukin-2 receptor subunit alpha ac Interleukin 2 receptor subunit alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10p15.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL2RA.

p55
CD25
IL2R
IMD41
TCGFR
IDDM10

Llyfryddiaeth

"Expression of CD25 on leukemic stem cells in BCR-ABL1+ CML: Potential diagnostic value and functional implications. ". Exp Hematol. 2017. PMID 28457753.
"CD25 Expression in B Lymphoblastic Leukemia/Lymphoma Predicts t(9;22)(q34;q11)/Philadelphia Chromosome Translocation (Ph) and Is Associated With Residual Disease in Ph-Negative Patients. ". Am J Clin Pathol. 2016. PMID 28430957.
"CD25 as an adverse prognostic factor in elderly patients with acute myeloid leukemia. ". Hematology. 2017. PMID 28097942.
"The serum concentration of soluble interleukin-2 receptor in patients with Kawasaki disease. ". Ann Clin Biochem. 2017. PMID 28081636.
"Interleukin-2 receptor-α proximal promoter hypomethylation is associated with multiple sclerosis.". Genes Immun. 2017. PMID 28077880.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] IL2RA - Cronfa NCBI

[1]

[2]