IL7R

IL7R
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3DI2, 3DI3, 3UP1
Dynodwyr
Cyfenwau	IL7R, CD127, CDW127, IL-7R-alpha, IL7RA, ILRA, Interleukin-7 receptor-α, interleukin 7 receptor
Dynodwyr allanol	OMIM: 146661 HomoloGene: 1646 GeneCards: IL7R
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0003823, GO:0051635 antigen binding; • interleukin-7 receptor activity; • GO:0001948, GO:0016582 protein binding; • GO:0016518 cytokine receptor activity;
Cydrannau o'r gell	• integral component of membrane; • bilen; • Cellbilen; • extracellular region; • external side of plasma membrane; • clathrin-coated vesicle membrane;
Prosesau biolegol	• regulation of cell size; • regulation of DNA recombination; • positive regulation of T cell differentiation in thymus; • homeostasis of number of cells; • negative regulation of T cell mediated cytotoxicity; • cell surface receptor signaling pathway; • B cell proliferation; • T cell differentiation; • GO:1901313 positive regulation of gene expression; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • GO:0000767 cell morphogenesis; • lymph node development; • immunoglobulin production; • GO:0072468 signal transduction; • interleukin-7-mediated signaling pathway; • positive regulation of cell population proliferation; • positive regulation of receptor signaling pathway via STAT; • membrane organization; • negative regulation of T cell apoptotic process;
	Sources:Amigo / QuickGO
Orthologau
	3575
	n/a
	ENSG00000168685
	n/a
	P16871
	n/a
	NM_002185
	n/a
	NP_002176
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IL7R yw IL7R a elwir hefyd yn Interleukin-7 receptor subunit alpha ac Interleukin 7 receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5p13.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL7R.

ILRA
CD127
IL7RA
CDW127
IL-7R-alpha

Llyfryddiaeth

"Identification of Heterozygous Single- and Multi-exon Deletions in IL7R by Whole Exome Sequencing. ". J Clin Immunol. 2017. PMID 27807805.
"Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity. ". Haematologica. 2016. PMID 27470599.
"Interleukin 7 receptor polymorphisms and the risk of multiple sclerosis: A meta-analysis. ". Mult Scler Relat Disord. 2016. PMID 27456877.
"Therapeutic targeting of IL-7Rα signaling pathways in ALL treatment. ". Blood. 2016. PMID 27268088.
"Association between the IL7R T244I polymorphism and multiple sclerosis risk: a meta analysis.". Neurol Sci. 2016. PMID 27188999.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] IL7R - Cronfa NCBI

[1]

[2]