ITGB2

ITGB2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1L3Y, 1YUK, 2JF1, 2P26, 2P28, 3K6S, 3K71, 3K72, 2V7D, 4NEH, 4NEN, 5E6X, 5E6V, 5E6S, 5E6R, 5E6W, 5ES4, 5E6U
Dynodwyr
Cyfenwau	ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7, integrin subunit beta 2
Dynodwyr allanol	OMIM: 600065 HomoloGene: 20092 GeneCards: ITGB2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0032403 protein-containing complex binding; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • protein heterodimerization activity; • ICAM-3 receptor activity; • protein kinase binding; • cell adhesion molecule binding; • heat shock protein binding; • amyloid-beta binding; • complement component C3b binding; • integrin binding; • signaling receptor activity; • cargo receptor activity;
Cydrannau o'r gell	• integral component of membrane; • extracellular vesicle; • integrin alphaL-beta2 complex; • bilen; • Cellbilen; • receptor complex; • cell surface; • integrin complex; • extracellular exosome; • specific granule membrane; • tertiary granule membrane; • ficolin-1-rich granule membrane; • focal adhesion; • external side of plasma membrane; • integrin alphaM-beta2 complex; • plasma membrane raft; • membrane raft; • cytoplasmic region; • GO:0009327 protein-containing complex;
Prosesau biolegol	• leukocyte cell-cell adhesion; • endodermal cell differentiation; • toll-like receptor 4 signaling pathway; • positive regulation of nitric oxide biosynthetic process; • heterotypic cell-cell adhesion; • cell-cell signaling; • GO:0010260 heneiddio; • receptor internalization; • leukocyte migration involved in inflammatory response; • natural killer cell activation; • cellular response to low-density lipoprotein particle stimulus; • extracellular matrix organization; • receptor clustering; • positive regulation of angiogenesis; • neutrophil chemotaxis; • cell adhesion; • positive regulation of NF-kappaB transcription factor activity; • regulation of cell shape; • regulation of immune response; • cellular extravasation; • integrin-mediated signaling pathway; • cell-matrix adhesion; • inflammatory response; • endothelial cell migration; • leukocyte migration; • regulation of peptidyl-tyrosine phosphorylation; • GO:0097285 apoptotic process; • ffagocytosis; • neutrophil degranulation; • microglial cell activation; • receptor-mediated endocytosis; • phagocytosis, engulfment; • cell migration; • cytokine-mediated signaling pathway; • positive regulation of superoxide anion generation; • cell adhesion mediated by integrin; • positive regulation of neutrophil degranulation; • negative regulation of dopamine metabolic process; • positive regulation of protein targeting to membrane; • amyloid-beta clearance; • cell-cell adhesion; • cell-cell adhesion via plasma-membrane adhesion molecules; • positive regulation of neuron death; • positive regulation of microglial cell activation; • neutrophil migration; • positive regulation of prostaglandin-E synthase activity; • positive regulation of leukocyte adhesion to vascular endothelial cell;
	Sources:Amigo / QuickGO
Orthologau
	3689
	n/a
	ENSG00000160255
	n/a
	P05107
	n/a
	NM_000211; NM_001127491; NM_001303238
	n/a
	NP_000202; NP_001120963; NP_001290167
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ITGB2 yw ITGB2 a elwir hefyd yn Integrin beta ac Integrin subunit beta 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 21, band 21q22.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ITGB2.

LAD
CD18
MF17
MFI7
LCAMB
LFA-1
MAC-1

Llyfryddiaeth

"Altered levels of soluble CD18 may associate immune mechanisms with outcome in sepsis. ". Clin Exp Immunol. 2017. PMID 28714582.
"LFA-1 Activation in NK Cells and Their Subsets: Influence of Receptors, Maturation, and Cytokine Stimulation. ". J Immunol. 2017. PMID 28100681.
"Quantitative Protein Sulfenic Acid Analysis Identifies Platelet Releasate-Induced Activation of Integrin β2 on Monocytes via NADPH Oxidase. ". J Proteome Res. 2016. PMID 27690452.
"CD18 promoter methylation is associated with a higher risk of thrombotic complications in primary myelofibrosis. ". Ann Hematol. 2016. PMID 27595148.
"LFA-1 integrin antibodies inhibit leukocyte α4β1-mediated adhesion by intracellular signaling.". Blood. 2016. PMID 27443292.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ITGB2 - Cronfa NCBI

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[2]