KCNA4

KCNA4
Dynodwyr
Cyfenwau	KCNA4, HBK4, HK1, HPCN2, HUKII, KCNA4L, KCNA8, KV1.4, PCN2, potassium voltage-gated channel subfamily A member 4, MCIDDS
Dynodwyr allanol	OMIM: 176266 HomoloGene: 20514 GeneCards: KCNA4
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• potassium channel activity; • potassium ion binding; • voltage-gated ion channel activity; • ion channel activity; • GO:0001948, GO:0016582 protein binding; • voltage-gated potassium channel activity; • delayed rectifier potassium channel activity;
Cydrannau o'r gell	• integral component of membrane; • cell projection; • bilen; • voltage-gated potassium channel complex; • Cellbilen; • axon; • integral component of plasma membrane; • dendritic spine;
Prosesau biolegol	• regulation of ion transmembrane transport; • cludo ïon; • potassium ion transport; • transmembrane transport; • potassium ion transmembrane transport; • protein homooligomerization;
	Sources:Amigo / QuickGO
Orthologau
	3739
	n/a
	ENSG00000182255
	n/a
	P22459
	n/a
	NM_002233
	n/a
	NP_002224
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KCNA4 yw KCNA4 a elwir hefyd yn Potassium voltage-gated channel subfamily A member 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p14.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KCNA4.

HK1
HBK4
PCN2
HPCN2
HUKII
KCNA8
KV1.4
KCNA4L

Llyfryddiaeth

"Identification of an evolutionarily conserved extracellular threonine residue critical for surface expression and its potential coupling of adjacent voltage-sensing and gating domains in voltage-gated potassium channels. ". J Biol Chem. 2008. PMID 18640987.
"Ginsenoside Rg3 inhibits human Kv1.4 channel currents by interacting with the Lys531 residue. ". Mol Pharmacol. 2008. PMID 17959711.
"Episodic ataxia type 1 mutations in the KCNA1 gene impair the fast inactivation properties of the human potassium channels Kv1.4-1.1/Kvbeta1.1 and Kv1.4-1.1/Kvbeta1.2. ". Eur J Neurosci. 2006. PMID 17156368.
"N type rapid inactivation in human Kv1.4 channels: functional role of a putative C-terminal helix. ". Mol Membr Biol. 2005. PMID 16308273.
"Molecular determinants of intracellular pH modulation of human Kv1.4 N-type inactivation.". Mol Pharmacol. 2002. PMID 12065763.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] KCNA4 - Cronfa NCBI

[1]

[2]