KIF22

KIF22
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2EDU, 3BFN
Dynodwyr
Cyfenwau	KIF22, A-328A3.2, KID, KNSL4, OBP, OBP-1, OBP-2, SEMDJL2, kinesin family member 22
Dynodwyr allanol	OMIM: 603213 HomoloGene: 32011 GeneCards: KIF22
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • nucleotide binding; • microtubule binding; • ATPase activity; • GO:0001948, GO:0016582 protein binding; • ATP binding; • microtubule motor activity;
Cydrannau o'r gell	• kinesin complex; • spindle; • chromatin; • mitotic spindle; • microtubule; • Cytosgerbwd; • kinetochore; • cnewyllyn cell; • cytoplasm; • cytosol; • nuclear speck;
Prosesau biolegol	• metaphase plate congression; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • sister chromatid cohesion; • microtubule-based movement; • mitotic metaphase plate congression; • GO:0100026 DNA repair; • retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; • GO:0007067 Mitosis;
	Sources:Amigo / QuickGO
Orthologau
	3835
	n/a
	ENSG00000079616
	n/a
	Q14807
	n/a
	NM_001256269; NM_001256270; NM_007317
	n/a
	NP_001243198; NP_001243199; NP_015556
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KIF22 yw KIF22 a elwir hefyd yn Kinesin family member 22 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16p11.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KIF22.

KID
OBP
KNSL4
OBP-1
OBP-2
SEMDJL2
A-328A3.2

Llyfryddiaeth

"Recurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity. ". Am J Hum Genet. 2011. PMID 22152678.
"Whole-exome sequencing identifies mutations of KIF22 in spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type. ". Am J Hum Genet. 2011. PMID 22152677.
"Human Kid is degraded by the APC/C(Cdh1) but not by the APC/C(Cdc20). ". Cell Cycle. 2007. PMID 17726374.
"The chromokinesin Kid is required for maintenance of proper metaphase spindle size. ". Mol Biol Cell. 2005. PMID 16176979.
"The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles.". J Cell Biol. 2001. PMID 11564754.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] KIF22 - Cronfa NCBI

[1]

[2]