KLC2

KLC2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3CEQ, 3EDT
Dynodwyr
Cyfenwau	KLC2, kinesin light chain 2
Dynodwyr allanol	OMIM: 611729 HomoloGene: 22468 GeneCards: KLC2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• microtubule motor activity; • GO:0001948, GO:0016582 protein binding; • kinesin binding; • cadherin binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • microtubule; • Cytosgerbwd; • bilen; • kinesin I complex; • kinesin complex; • nucleoplasm; • mitocondria; • Cellbilen; • GO:0009327 protein-containing complex;
Prosesau biolegol	• microtubule-based movement; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;
	Sources:Amigo / QuickGO
Orthologau
	64837
	n/a
	ENSG00000174996
	n/a
	Q9H0B6
	n/a
	NM_001134774; NM_001134775; NM_001134776; NM_022822; NM_001318734
	n/a
	NP_001128246; NP_001128247; NP_001128248; NP_001305663; NP_073733
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KLC2 yw KLC2 a elwir hefyd yn Kinesin light chain 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q13.2.^[2]

Llyfryddiaeth

"Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells. ". FASEB J. 2010. PMID 19773350.
"SRC mediates a switch from microtubule- to actin-based motility of vaccinia virus. ". Science. 2004. PMID 15297625.
"The light chains of kinesin-1 are autoinhibited. ". Proc Natl Acad Sci U S A. 2016. PMID 26884162.
"Overexpression of KLC2 due to a homozygous deletion in the non-coding region causes SPOAN syndrome. ". Hum Mol Genet. 2015. PMID 26385635.
"Crystal structures of the tetratricopeptide repeat domains of kinesin light chains: insight into cargo recognition mechanisms.". PLoS One. 2012. PMID 22470497.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] KLC2 - Cronfa NCBI

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[2]