KMT5A

KMT5A
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1ZKK, 2BQZ, 3F9W, 3F9X, 3F9Y, 3F9Z, 4IJ8, 5HQ2
Dynodwyr
Cyfenwau	KMT5A, PR-Set7, SET07, SET8, SETD8, lysine methyltransferase 5A, PR/SET07
Dynodwyr allanol	OMIM: 607240 HomoloGene: 41372 GeneCards: KMT5A
EC number	2.1.1.354
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein-lysine N-methyltransferase activity; • GO:0102674, GO:0102675 methyltransferase activity; • GO:0001106 transcription corepressor activity; • p53 binding; • GO:0001948, GO:0016582 protein binding; • transferase activity; • lysine N-methyltransferase activity; • histone-lysine N-methyltransferase activity; • histone methyltransferase activity (H4-K20 specific);
Cydrannau o'r gell	• cnewyllyn cell; • nucleoplasm; • Cromosom; • cytosol;
Prosesau biolegol	• methylation; • GO:0009373 regulation of transcription, DNA-templated; • peptidyl-lysine monomethylation; • cell cycle; • GO:1901227 negative regulation of transcription by RNA polymerase II; • GO:0045996 negative regulation of transcription, DNA-templated; • Cellraniad; • transcription, DNA-templated; • regulation of DNA damage response, signal transduction by p53 class mediator; • histone lysine methylation; • regulation of signal transduction by p53 class mediator; • histone H4-K20 methylation; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization;
	Sources:Amigo / QuickGO
Orthologau
	387893
	n/a
	ENSG00000183955
	n/a
	Q9NQR1
	n/a
NM_020382; NM_001324504; NM_001324505; NM_001324506; NM_001367386;
	NM_001367388; NM_001367389
	n/a
NP_001311433; NP_001311434; NP_001311435; NP_065115; NP_001354315;
	NP_001354317; NP_001354318
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KMT5A yw KMT5A a elwir hefyd yn Lysine methyltransferase 5A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q24.31.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KMT5A.

SET8
SET07
SETD8
PR-Set7

Llyfryddiaeth

"SET8 expression is associated with overall survival in gastric cancer. ". Genet Mol Res. 2015. PMID 26634528.
"SET8 methyltransferase activity during the DNA double-strand break response is required for recruitment of 53BP1. ". EMBO Rep. 2014. PMID 25252681.
"Functional polymorphism at the miR-502-binding site in the 3' untranslated region of the SETD8 gene increased the risk of prostate cancer in a sample of Iranian population. ". Gene. 2017. PMID 28578017.
"The SETD8/PR-Set7 Methyltransferase Functions as a Barrier to Prevent Senescence-Associated Metabolic Remodeling. ". Cell Rep. 2017. PMID 28249161.
"Multivalent Interactions by the Set8 Histone Methyltransferase With Its Nucleosome Substrate.". J Mol Biol. 2016. PMID 26953260.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] KMT5A - Cronfa NCBI

[1]

[2]