LEF1

LEF1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2LEF, 3OUW, 3OUX
Dynodwyr
Cyfenwau	LEF1, LEF-1, TCF10, TCF1ALPHA, TCF7L3, lymphoid enhancer binding factor 1
Dynodwyr allanol	HomoloGene: 7813 GeneCards: LEF1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • histone deacetylase binding; • armadillo repeat domain binding; • estrogen receptor binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • transcription factor binding; • estrogen receptor activity; • gamma-catenin binding; • GO:0031493 histone binding; • C2H2 zinc finger domain binding; • chromatin binding; • cysteine-type endopeptidase inhibitor activity involved in apoptotic process; • GO:0001948, GO:0016582 protein binding; • DNA binding, bending; • DNA binding; • sequence-specific DNA binding; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • beta-catenin binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cydrannau o'r gell	• cytoplasm; • cnewyllyn cell; • transcription regulator complex; • beta-catenin-TCF complex; • nucleoplasm; • protein-DNA complex;
Prosesau biolegol	• somitogenesis; • tongue development; • paraxial mesoderm formation; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • negative regulation of DNA binding; • T cell receptor V(D)J recombination; • transcription by RNA polymerase II; • cellular response to cytokine stimulus; • mammary gland development; • negative regulation of interleukin-13 production; • odontogenesis of dentin-containing tooth; • apoptotic process involved in blood vessel morphogenesis; • cell chemotaxis; • negative regulation of canonical Wnt signaling pathway; • face morphogenesis; • neutrophil differentiation; • negative regulation of interleukin-5 production; • GO:0009373 regulation of transcription, DNA-templated; • dentate gyrus development; • apoptotic process involved in morphogenesis; • transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of cell growth; • regulation of Wnt signaling pathway; • embryonic limb morphogenesis; • hypothalamus development; • branching involved in blood vessel morphogenesis; • trachea gland development; • regulation of striated muscle tissue development; • positive regulation of cell-cell adhesion; • forebrain neuroblast division; • eye pigmentation; • negative regulation of apoptotic process; • sprouting angiogenesis; • GO:1901227 negative regulation of transcription by RNA polymerase II; • positive regulation of epithelial to mesenchymal transition; • BMP signaling pathway; • positive regulation of cell cycle process; • osteoblast differentiation; • histone H3 acetylation; • formation of radial glial scaffolds; • positive regulation of granulocyte differentiation; • alpha-beta T cell differentiation; • canonical Wnt signaling pathway; • GO:0045996 negative regulation of transcription, DNA-templated; • sensory perception of taste; • cellular response to interleukin-4; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • cell development; • negative regulation of cell-cell adhesion; • negative regulation of interleukin-4 production; • negative regulation of striated muscle tissue development; • positive regulation of cell migration; • Wnt signaling pathway; • T-helper 1 cell differentiation; • positive regulation of cell proliferation in bone marrow; • anatomical structure regression; • chorio-allantoic fusion; • negative regulation of apoptotic process in bone marrow cell; • B cell proliferation; • GO:1901313 positive regulation of gene expression; • vasculature development; • forebrain radial glial cell differentiation; • neural crest cell migration; • positive regulation of cell population proliferation; • forebrain neuron differentiation; • histone H4 acetylation; • hippocampus development; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • Wnt signaling pathway, calcium modulating pathway; • steroid hormone mediated signaling pathway; • odontoblast differentiation; • beta-catenin-TCF complex assembly; • epithelial to mesenchymal transition; • regulation of cell-cell adhesion; • secondary palate development;
	Sources:Amigo / QuickGO
Orthologau
	51176
	n/a
	ENSG00000138795
	n/a
	Q9UJU2; Q659G9
	n/a
	NM_001130713; NM_001130714; NM_001166119; NM_016269
	n/a
	NP_001124185; NP_001124186; NP_001159591; NP_057353; NP_057353.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LEF1 yw LEF1 a elwir hefyd yn Lymphoid enhancer-binding factor 1, isoform CRA_b a Lymphoid enhancer binding factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q25.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LEF1.

LEF-1
TCF10
TCF7L3
TCF1ALPHA

Llyfryddiaeth

"Methylprednisolone suppresses the Wnt signaling pathway in chronic lymphocytic leukemia cell line MEC-1 regulated by LEF-1 expression. ". Int J Clin Exp Pathol. 2015. PMID 26339357.
"Overexpression of lymphoid enhancer-binding factor-1 (LEF1) is a novel favorable prognostic factor in childhood acute lymphoblastic leukemia. ". Int J Lab Hematol. 2015. PMID 25955539.
"Diagnostic Utility of Lymphoid Enhancer Binding Factor 1 Immunohistochemistry in Small B-Cell Lymphomas. ". Am J Clin Pathol. 2017. PMID 28395058.
"Expression of LEF1 in mantle cell lymphoma. ". Ann Diagn Pathol. 2017. PMID 28038713.
"High LEF1 expression predicts adverse prognosis in chronic lymphocytic leukemia and may be targeted by ethacrynic acid.". Oncotarget. 2016. PMID 26950276.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] LEF1 - Cronfa NCBI

[1]

[2]