LHX2

LHX2
Dynodwyr
Cyfenwau	LHX2, LH2, hLhx2, LIM homeobox 2
Dynodwyr allanol	OMIM: 603759 HomoloGene: 55848 GeneCards: LHX2
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• metal ion binding; • sequence-specific DNA binding; • chromatin binding; • DNA binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • transcription factor binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cydrannau o'r gell	• cnewyllyn cell; • intracellular anatomical structure;
Prosesau biolegol	• negative regulation of transcription regulatory region DNA binding; • mesoderm development; • telencephalon development; • neural tube closure; • retina development in camera-type eye; • cerebral cortex development; • transcription, DNA-templated; • axon guidance; • axon extension; • hair follicle development; • maintenance of epithelial cell apical/basal polarity; • neurogenesis; • brain development; • olfactory bulb development; • nervous system development; • dorsal/ventral pattern formation; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • GO:0009373 regulation of transcription, DNA-templated; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • neuron differentiation; • anatomical structure formation involved in morphogenesis; • telencephalon regionalization; • transcription by RNA polymerase II; • negative regulation of gene expression, epigenetic; • negative regulation of neurogenesis; • positive regulation of neural precursor cell proliferation;
	Sources:Amigo / QuickGO
Orthologau
	9355
	n/a
	ENSG00000106689
	n/a
	P50458
	n/a
	NM_004789
	n/a
	NP_004780
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LHX2 yw LHX2 a elwir hefyd yn LIM homeobox 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q33.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LHX2.

LH2
hLhx2

Llyfryddiaeth

"Mutations in the LHX2 gene are not a frequent cause of micro/anophthalmia. ". Mol Vis. 2010. PMID 21203406.
"Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1. ". Oncogene. 1996. PMID 8649822.
"Oncogenicity of LHX2 in pancreatic ductal adenocarcinoma. ". Mol Biol Rep. 2014. PMID 25324171.
"LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1. ". Nucleic Acids Res. 2013. PMID 23804753.
"Screening of LHX2 in patients presenting growth retardation with posterior pituitary and ocular abnormalities.". Eur J Endocrinol. 2012. PMID 22535646.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] LHX2 - Cronfa NCBI

[1]

[2]