LIF

LIF
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1EMR, 1PVH, 2Q7N
Dynodwyr
Cyfenwau	LIF, CDF, DIA, HILDA, MLPLI, leukemia inhibitory factor, interleukin 6 family cytokine, LIF interleukin 6 family cytokine
Dynodwyr allanol	OMIM: 159540 HomoloGene: 1734 GeneCards: LIF
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• signaling receptor binding; • growth factor activity; • cytokine activity; • GO:0001948, GO:0016582 protein binding; • leukemia inhibitory factor receptor binding;
Cydrannau o'r gell	• extracellular region; • extracellular space; • cytosol;
Prosesau biolegol	• negative regulation of cell population proliferation; • stem cell differentiation; • positive regulation of peptidyl-serine phosphorylation of STAT protein; • positive regulation of MAPK cascade; • positive regulation of peptidyl-serine phosphorylation; • spongiotrophoblast differentiation; • lung development; • positive regulation of histone H3-K27 acetylation; • multicellular organism development; • lung lobe morphogenesis; • muscle organ morphogenesis; • maternal process involved in female pregnancy; • negative regulation of hormone secretion; • leukemia inhibitory factor signaling pathway; • regulation of metanephric nephron tubule epithelial cell differentiation; • regulation of cell differentiation; • GO:1901313 positive regulation of gene expression; • stem cell population maintenance; • positive regulation of peptidyl-tyrosine phosphorylation; • regulation of RNA polymerase II regulatory region sequence-specific DNA binding; • positive regulation of astrocyte differentiation; • negative regulation of ERK1 and ERK2 cascade; • neuron development; • decidualization; • positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; • lung alveolus development; • positive regulation of macrophage differentiation; • blood vessel remodeling; • trophoblast giant cell differentiation; • lung vasculature development; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of protein localization to nucleus; • embryo implantation; • negative regulation of meiotic nuclear division; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • positive regulation of cell population proliferation; • positive regulation of tyrosine phosphorylation of STAT protein; • tyrosine phosphorylation of STAT protein; • regulation of signaling receptor activity; • cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	3976
	n/a
	ENSG00000128342
	n/a
	P15018
	n/a
	NM_001257135; NM_002309
	n/a
	NP_001244064; NP_002300
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LIF yw LIF a elwir hefyd yn LIF, interleukin 6 family cytokine (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q12.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LIF.

CDF
DIA
HILDA
MLPLI

Llyfryddiaeth

"The Multifaceted Actions of Leukaemia Inhibitory Factor in Mediating Uterine Receptivity and Embryo Implantation. ". Am J Reprod Immunol. 2016. PMID 26817565.
"Integrin αVβ3 and αVβ5 are required for leukemia inhibitory factor-mediated the adhesion of trophoblast cells to the endometrial cells. ". Biochem Biophys Res Commun. 2016. PMID 26723254.
"Leukemia inhibitory factor promotes EMT through STAT3-dependent miR-21 induction. ". Oncotarget. 2016. PMID 26716902.
"Association between leukaemia inhibitory factor gene polymorphism and pregnancy outcomes after assisted reproduction techniques. ". Reprod Biomed Online. 2016. PMID 26615902.
"Leukemia inhibitory factor promotes tumor growth and metastasis in human osteosarcoma via activating STAT3.". APMIS. 2015. PMID 26271643.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] LIF - Cronfa NCBI

[1]

[2]