LMAN1

LMAN1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3A4U, 3LCP, 3WHT, 3WHU, 3WNX, 4GKX, 4GKY, 4YGC, 4YGD, 4YGE, 4YGB
Dynodwyr
Cyfenwau	LMAN1, ERGIC-53, ERGIC53, F5F8D, FMFD1, MCFD1, MR60, gp58, lectin, mannose binding 1
Dynodwyr allanol	OMIM: 601567 HomoloGene: 4070 GeneCards: LMAN1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• unfolded protein binding; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • mannose binding; • carbohydrate binding;
Cydrannau o'r gell	• integral component of membrane; • Golgi apparatus; • Golgi membrane; • sarcomere; • host cell perinuclear region of cytoplasm; • Reticwlwm endoplasmig; • ER to Golgi transport vesicle membrane; • extracellular exosome; • endoplasmic reticulum membrane; • endoplasmic reticulum-Golgi intermediate compartment; • bilen; • endoplasmic reticulum-Golgi intermediate compartment membrane; • COPII-coated ER to Golgi transport vesicle;
Prosesau biolegol	• Golgi organization; • early endosome to Golgi transport; • blood coagulation; • positive regulation of organelle organization; • protein N-linked glycosylation via asparagine; • COPII vesicle coating; • protein exit from endoplasmic reticulum; • protein folding; • protein transport; • vesicle-mediated transport; • endoplasmic reticulum to Golgi vesicle-mediated transport; • endoplasmic reticulum organization; • GO:0015915 transport;
	Sources:Amigo / QuickGO
Orthologau
	3998
	n/a
	ENSG00000074695
	n/a
	P49257
	n/a
	NM_005570
	n/a
	NP_005561
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LMAN1 yw LMAN1 a elwir hefyd yn Lectin, mannose binding 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 18, band 18q21.32.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LMAN1.

MR60
gp58
F5F8D
FMFD1
MCFD1
ERGIC53
ERGIC-53

Llyfryddiaeth

"Mannose-binding lectin (MBL) codon 54 (rs1800450) polymorphism predisposes towards medium vessel vasculitis in patients with systemic lupus erythematosus. ". Clin Rheumatol. 2017. PMID 28097447.
"Mannan-binding lectin reduces CpG DNA-induced inflammatory cytokine production by human monocytes. ". Microbiol Immunol. 2015. PMID 25664598.
"The intracellular cargo receptor ERGIC-53 is required for the production of infectious arenavirus, coronavirus, and filovirus particles. ". Cell Host Microbe. 2013. PMID 24237698.
"Two new mutations at ERGIC-53 gene in a Turkish family. ". Clin Appl Thromb Hemost. 2011. PMID 20460353.
"High frequency of LMAN1 abnormalities in colorectal tumors with microsatellite instability.". Cancer Res. 2009. PMID 19118014.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] LMAN1 - Cronfa NCBI

[1]

[2]