LMO2

LMO2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2XJY, 2XJZ, 2YPA, 4KFZ
Dynodwyr
Cyfenwau	LMO2, RBTN2, RBTNL1, RHOM2, TTG2, LIM domain only 2, LMO-2
Dynodwyr allanol	OMIM: 180385 HomoloGene: 4072 GeneCards: LMO2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • bHLH transcription factor binding; • E-box binding; • GO:0001948, GO:0016582 protein binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • metal ion binding;
Cydrannau o'r gell	• cnewyllyn cell; • transcription regulator complex; • nucleoplasm;
Prosesau biolegol	• multicellular organism development; • mRNA transcription by RNA polymerase II; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • cellular response to thyroid hormone stimulus; • regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
Orthologau
	4005
	n/a
	ENSG00000135363
	n/a
	P25791
	n/a
	NM_001142315; NM_001142316; NM_005574
	n/a
	NP_001135787; NP_001135788; NP_005565
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LMO2 yw LMO2 a elwir hefyd yn LIM domain only 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p13.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LMO2.

TTG2
LMO-2
RBTN2
RHOM2
RBTNL1

Llyfryddiaeth

"LMO2-negative Expression Predicts the Presence of MYC Translocations in Aggressive B-Cell Lymphomas. ". Am J Surg Pathol. 2017. PMID 28288039.
"Activation of the LMO2oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia. ". Blood. 2017. PMID 28270453.
"Overexpression of LMO2 causes aberrant human T-Cell development in vivo by three potentially distinct cellular mechanisms. ". Exp Hematol. 2016. PMID 27302866.
"LMO2 Is a Specific Marker of T-Lymphoblastic Leukemia/Lymphoma. ". Am J Clin Pathol. 2016. PMID 26796495.
"The LIM-only transcription factor LMO2 determines tumorigenic and angiogenic traits in glioma stem cells.". Cell Death Differ. 2015. PMID 25721045.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] LMO2 - Cronfa NCBI

[1]

[2]