LRPAP1

LRPAP1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1LRE, 1NRE, 1OP1, 1OV2, 2FCW, 2FTU, 2FYL, 2P01, 2P03
Dynodwyr
Cyfenwau	LRPAP1, A2MRAP, A2RAP, HBP44, MRAP, MYP23, RAP, alpha-2-MRAP, LDL-receptor-related protein associated protein, LDL receptor related protein associated protein 1
Dynodwyr allanol	OMIM: 104225 HomoloGene: 37612 GeneCards: LRPAP1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• lipase binding; • very-low-density lipoprotein particle receptor binding; • low-density lipoprotein particle receptor binding; • GO:0001948, GO:0016582 protein binding; • signaling receptor binding; • heparin binding; • receptor antagonist activity; • amyloid-beta binding;
Cydrannau o'r gell	• cytoplasm; • fesigl; • cell surface; • Reticwlwm endoplasmig; • rough endoplasmic reticulum; • extracellular region; • endosome; • endoplasmic reticulum-Golgi intermediate compartment; • Golgi apparatus; • Golgi lumen; • cis-Golgi network; • Cellbilen; • endosome lumen; • rough endoplasmic reticulum lumen;
Prosesau biolegol	• negative regulation of protein binding; • negative regulation of very-low-density lipoprotein particle clearance; • negative regulation of amyloid-beta clearance; • regulation of receptor-mediated endocytosis; • extracellular negative regulation of signal transduction; • negative regulation of receptor internalization; • negative regulation of cell death; • amyloid-beta clearance by transcytosis; • positive regulation of amyloid-beta clearance; • negative regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologau
	4043
	n/a
	ENSG00000163956
	n/a
	P30533
	n/a
	NM_002337
	n/a
	NP_002328
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LRPAP1 yw LRPAP1 a elwir hefyd yn LDL receptor related protein associated protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4p16.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LRPAP1.

RAP
MRAP
A2RAP
HBP44
MYP23
A2MRAP
alpha-2-MRAP

Llyfryddiaeth

"Clinical Characterization of LRPAP1-Related Pediatric High Myopia. ". Ophthalmology. 2016. PMID 26271838.
"Receptor-associated protein blocks internalization and cytotoxicity of myeloma light chain in cultured human proximal tubular cells. ". PLoS One. 2013. PMID 23894629.
"Inhibition of Abeta aggregation and neurotoxicity by the 39-kDa receptor-associated protein. ". J Neurochem. 2010. PMID 20002523.
"Sequencing of the entire coding region of the receptor associated protein (RAP) in patients with primary hypothyroidism of unknown origin. ". J Endocrinol Invest. 2007. PMID 18075286.
"Lipoprotein receptor associated protein (LRPAP1) insertion/deletion polymorphism: association with gallbladder cancer susceptibility.". Int J Gastrointest Cancer. 2006. PMID 17987404.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] LRPAP1 - Cronfa NCBI

[1]

[2]