MAD1L1

MAD1L1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4DZO, 1GO4
Dynodwyr
Cyfenwau	MAD1L1, PIG9, TP53I9, TXBP181, MAD1, MAD1 mitotic arrest deficient like 1, mitotic arrest deficient 1 like 1
Dynodwyr allanol	OMIM: 602686 HomoloGene: 74500 GeneCards: MAD1L1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • kinetochore binding; • identical protein binding;
Cydrannau o'r gell	• centrosome; • spindle pole; • spindle; • nuclear pore; • Cromosom; • microtubule organizing center; • mitotic spindle; • chromosome, centromeric region; • Cytosgerbwd; • kinetochore; • cytoplasm; • mitotic spindle pole; • nuclear envelope; • cnewyllyn cell; • cytosol; • nuclear pore nuclear basket;
Prosesau biolegol	• regulation of mitotic cell cycle phase transition; • regulation of metaphase plate congression; • mitotic cell cycle checkpoint signaling; • thymus development; • Cellraniad; • negative regulation of T cell proliferation; • cell cycle; • mitotic spindle assembly checkpoint signaling; • attachment of mitotic spindle microtubules to kinetochore;
	Sources:Amigo / QuickGO
Orthologau
	8379
	n/a
	ENSG00000002822
	n/a
	Q9Y6D9
	n/a
NM_001013836; NM_001013837; NM_001304523; NM_001304524; NM_001304525;
	NM_003550
	n/a
NP_001013858; NP_001013859; NP_001291452; NP_001291453; NP_001291454;
	NP_003541
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAD1L1 yw MAD1L1 a elwir hefyd yn Mitotic spindle assembly checkpoint protein MAD1 a Mitotic arrest deficient 1 like 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7p22.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAD1L1.

MAD1
PIG9
TP53I9
TXBP181

Llyfryddiaeth

"Investigating the Impact of a Genome-Wide Supported Bipolar Risk Variant of MAD1L1 on the Human Reward System. ". Neuropsychopharmacology. 2016. PMID 27184339.
"The spindle assembly checkpoint promotes chromosome bi-orientation: A novel Mad1 role in chromosome alignment. ". Cell Cycle. 2016. PMID 26752263.
"Genetic association of GWAS-supported MAD1L1 gene polymorphism rs12666575 with schizophrenia susceptibility in a Chinese population. ". Neurosci Lett. 2016. PMID 26528791.
"Mitotic arrest deficient-like 1 is correlated with poor prognosis in small-cell lung cancer after surgical resection. ". Tumour Biol. 2016. PMID 26499943.
"A Golgi-localized pool of the mitotic checkpoint component Mad1 controls integrin secretion and cell migration.". Curr Biol. 2014. PMID 25447996.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MAD1L1 - Cronfa NCBI

[1]

[2]