MAP2K1

MAP2K1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1S9J, 2P55, 3DV3, 3DY7, 3E8N, 3EQB, 3EQC, 3EQD, 3EQF, 3EQG, 3EQH, 3EQI, 3MBL, 3ORN, 3OS3, 3PP1, 3SLS, 3V01, 3V04, 3VVH, 3W8Q, 3WIG, 3ZLS, 3ZLW, 3ZLX, 3ZLY, 3ZM4, 4AN2, 4AN3, 4AN9, 4ANB, 4ARK, 4LMN, 4MNE, 4U7Z, 4U80, 4U81, 5BX0
Dynodwyr
Cyfenwau	MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1, mitogen-activated protein kinase kinase 1, MEL
Dynodwyr allanol	OMIM: 176872 HomoloGene: 2063 GeneCards: MAP2K1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein N-terminus binding; • kinase activity; • protein C-terminus binding; • ATP binding; • transferase activity; • protein serine/threonine kinase activator activity; • GO:0001948, GO:0016582 protein binding; • protein serine/threonine/tyrosine kinase activity; • protein tyrosine kinase activity; • nucleotide binding; • MAP kinase kinase activity; • protein kinase activity; • protein serine/threonine kinase activity; • scaffold protein binding;
Cydrannau o'r gell	• bilen; • focal adhesion; • microtubule organizing center; • mitocondria; • Cytosgerbwd; • cnewyllyn cell; • Reticwlwm endoplasmig; • late endosome; • Golgi apparatus; • early endosome; • cytoplasm; • cytosol; • Cellbilen;
Prosesau biolegol	• regulation of protein phosphorylation; • positive regulation of axonogenesis; • positive regulation of protein serine/threonine kinase activity; • cellular senescence; • face development; • cerebellar cortex formation; • negative regulation of cell population proliferation; • thymus development; • cell motility; • negative regulation of gene expression; • heart development; • positive regulation of cell differentiation; • regulation of stress-activated MAPK cascade; • phosphorylation; • epithelial cell proliferation involved in lung morphogenesis; • chemotaxis; • thyroid gland development; • neuron differentiation; • trachea formation; • regulation of axon regeneration; • lung morphogenesis; • regulation of early endosome to late endosome transport; • labyrinthine layer development; • placenta blood vessel development; • keratinocyte differentiation; • MAPK cascade; • GO:1901313 positive regulation of gene expression; • Bergmann glial cell differentiation; • peptidyl-tyrosine phosphorylation; • regulation of Golgi inheritance; • GO:0072468 signal transduction; • positive regulation of production of miRNAs involved in gene silencing by miRNA; • positive regulation of ERK1 and ERK2 cascade; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • regulation of mitotic cell cycle; • regulation of apoptotic process; • protein phosphorylation; • peptidyl-threonine phosphorylation; • ERK1 and ERK2 cascade; • stress-activated protein kinase signaling cascade; • activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologau
	5604
	n/a
	ENSG00000169032
	n/a
	Q02750
	n/a
	NM_002755
	n/a
	NP_002746
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAP2K1 yw MAP2K1 a elwir hefyd yn Mitogen-activated protein kinase kinase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q22.31.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAP2K1.

CFC3
MEK1
MKK1
MAPKK1
PRKMK1

Llyfryddiaeth

"Sensitive methods for screening of the MEK1 gene mutations in patients with central nervous system metastases of non-small cell lung cancer. ". Clin Transl Oncol. 2016. PMID 26860843.
"MEK Inhibitor Selumetinib (AZD6244; ARRY-142886) Prevents Lung Metastasis in a Triple-Negative Breast Cancer Xenograft Model. ". Mol Cancer Ther. 2015. PMID 26384399.
"Somatic MAP2K1 Mutations Are Associated with Extracranial Arteriovenous Malformation. ". Am J Hum Genet. 2017. PMID 28190454.
"Variability in clinical and neuropsychological features of individuals with MAP2K1 mutations. ". Am J Med Genet A. 2017. PMID 27862862.
"A Phos-tag SDS-PAGE method that effectively uses phosphoproteomic data for profiling the phosphorylation dynamics of MEK1.". Proteomics. 2016. PMID 27169363.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MAP2K1 - Cronfa NCBI

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[2]