MAP2K2

MAP2K2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1S9I, 4H3Q
Dynodwyr
Cyfenwau	MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2, mitogen-activated protein kinase kinase 2
Dynodwyr allanol	OMIM: 601263 HomoloGene: 48591 GeneCards: MAP2K2
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • protein kinase activity; • PDZ domain binding; • scaffold protein binding; • protein serine/threonine kinase activator activity; • metal ion binding; • kinase activity; • GO:0001948, GO:0016582 protein binding; • protein serine/threonine/tyrosine kinase activity; • protein tyrosine kinase activity; • ATP binding; • MAP kinase kinase activity; • protein serine/threonine kinase activity;
Cydrannau o'r gell	• late endosome; • Golgi apparatus; • bilen; • focal adhesion; • cell-cell junction; • peroxisomal membrane; • extracellular region; • early endosome; • Reticwlwm endoplasmig; • mitocondria; • perinuclear region of cytoplasm; • cytoplasmic side of plasma membrane; • microtubule; • cnewyllyn cell; • cytoplasm; • cytosol; • Cellbilen;
Prosesau biolegol	• phosphorylation; • regulation of early endosome to late endosome transport; • peptidyl-serine autophosphorylation; • negative regulation of gene expression; • positive regulation of protein serine/threonine kinase activity; • protein phosphorylation; • peptidyl-tyrosine phosphorylation; • regulation of Golgi inheritance; • regulation of stress-activated MAPK cascade; • MAPK cascade; • ERK1 and ERK2 cascade; • positive regulation of production of miRNAs involved in gene silencing by miRNA; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of ERK1 and ERK2 cascade; • regulation of mitotic cell cycle; • regulation of apoptotic process; • GO:0072468 signal transduction; • stress-activated protein kinase signaling cascade; • activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologau
	5605
	n/a
	ENSG00000126934
	n/a
	P36507
	n/a
	NM_030662
	n/a
	NP_109587
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAP2K2 yw MAP2K2 a elwir hefyd yn Mitogen-activated protein kinase kinase 2, isoform CRA_d a Mitogen-activated protein kinase kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19p13.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAP2K2.

CFC4
MEK2
MKK2
MAPKK2
PRKMK2

Llyfryddiaeth

"Deletion of MAP2K2/MEK2: a novel mechanism for a RASopathy?". Clin Genet. 2014. PMID 23379592.
"A full-length 3D structure for MAPK/ERK kinase 2 (MEK2). ". Sci China Life Sci. 2011. PMID 21509657.
"Concurrent occurrence of an inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving MAP2K2 in a patient with developmental delay, distinctive facial features, and lambdoid synostosis. ". Eur J Med Genet. 2016. PMID 27751966.
"Familial cardiofaciocutaneous syndrome in a father and a son with a novel MEK2 mutation. ". Am J Med Genet A. 2015. PMID 25487361.
"Multiple café au lait spots in familial patients with MAP2K2 mutation.". Am J Med Genet A. 2014. PMID 24311457.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MAP2K2 - Cronfa NCBI

[1]

[2]