MAP3K7

MAP3K7
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2EVA, 2YIY, 4GS6, 4L3P, 4L52, 4L53, 4O91, 5JGD, 5JGA
Dynodwyr
Cyfenwau	MAP3K7, MEKK7, TAK1, TGF1a, mitogen-activated protein kinase kinase kinase 7, FMD2, CSCF
Dynodwyr allanol	OMIM: 602614 HomoloGene: 135715 GeneCards: MAP3K7
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • protein kinase activity; • nucleotide binding; • scaffold protein binding; • metal ion binding; • kinase activity; • protein serine/threonine kinase activity; • GO:0001948, GO:0016582 protein binding; • ATP binding; • magnesium ion binding; • MAP kinase kinase kinase activity; • identical protein binding; • receptor tyrosine kinase binding;
Cydrannau o'r gell	• cytosol; • bilen; • Cellbilen; • endosome membrane; • cnewyllyn cell; • IkappaB kinase complex; • cytoplasm;
Prosesau biolegol	• GO:0009373 regulation of transcription, DNA-templated; • phosphorylation; • positive regulation of JUN kinase activity; • stimulatory C-type lectin receptor signaling pathway; • activation of NF-kappaB-inducing kinase activity; • I-kappaB phosphorylation; • MyD88-dependent toll-like receptor signaling pathway; • transcription, DNA-templated; • Fc-epsilon receptor signaling pathway; • protein phosphorylation; • JNK cascade; • positive regulation of T cell activation; • positive regulation of NF-kappaB transcription factor activity; • positive regulation of interleukin-2 production; • positive regulation of T cell cytokine production; • histone H3 acetylation; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • I-kappaB kinase/NF-kappaB signaling; • transforming growth factor beta receptor signaling pathway; • T cell receptor signaling pathway; • nucleotide-binding oligomerization domain containing signaling pathway; • GO:0072468 signal transduction; • GO:0097285 apoptotic process; • Wnt signaling pathway, calcium modulating pathway; • stress-activated MAPK cascade; • positive regulation of macroautophagy; • protein deubiquitination; • anoikis; • MyD88-independent toll-like receptor signaling pathway; • GO:0022415 viral process; • interleukin-1-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	6885
	n/a
	ENSG00000135341
	n/a
	O43318
	n/a
	NM_003188; NM_145331; NM_145332; NM_145333
	n/a
	NP_003179; NP_663304; NP_663305; NP_663306
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAP3K7 yw MAP3K7 a elwir hefyd yn Mitogen-activated protein kinase kinase kinase 7 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q15.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAP3K7.

CSCF
FMD2
TAK1
MEKK7
TGF1a

Llyfryddiaeth

"Activation of TAK1 by Chemotactic and Growth Factors, and Its Impact on Human Neutrophil Signaling and Functional Responses. ". J Immunol. 2015. PMID 26491199.
"TAK1 is a key modulator of the profibrogenic phenotype of human ileal myofibroblasts in Crohn's disease. ". Am J Physiol Gastrointest Liver Physiol. 2015. PMID 26185333.
"Heterozygous Mutations in MAP3K7, Encoding TGF-β-Activated Kinase 1, Cause Cardiospondylocarpofacial Syndrome. ". Am J Hum Genet. 2016. PMID 27426734.
"TAK1 is involved in the autophagy process in retinal pigment epithelial cells. ". Biochem Cell Biol. 2016. PMID 26928052.
"The role of TAK1 expression in thyroid cancer.". Int J Clin Exp Pathol. 2015. PMID 26823762.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MAP3K7 - Cronfa NCBI

[1]

[2]