MAPK8IP1

MAPK8IP1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2G01, 2GMX, 2H96, 3OXI, 3PTG, 3VUD, 3VUG, 3VUH, 3VUI, 3VUK, 3VUL, 3VUM, 4E73, 4G1W, 4H39, 4HYS, 4HYU, 4IZY
Dynodwyr
Cyfenwau	MAPK8IP1, IB1, JIP-1, JIP1, PRKM8IP, mitogen-activated protein kinase 8 interacting protein 1
Dynodwyr allanol	OMIM: 604641 HomoloGene: 31314 GeneCards: MAPK8IP1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• MAP-kinase scaffold activity; • protein kinase inhibitor activity; • GO:0001948, GO:0016582 protein binding; • kinesin binding; • protein kinase binding; • JUN kinase binding; • mitogen-activated protein kinase kinase binding; • mitogen-activated protein kinase kinase kinase binding;
Cydrannau o'r gell	• cytoplasm; • cell body; • cytosol; • dendritic growth cone; • endoplasmic reticulum membrane; • mitochondrial membranes; • bilen; • dentate gyrus mossy fiber; • axonal growth cone; • synapse; • axon; • dendrite; • Reticwlwm endoplasmig; • mitocondria; • perinuclear region of cytoplasm; • neuron projection; • cnewyllyn cell; • Cellbilen;
Prosesau biolegol	• GO:0009373 regulation of transcription, DNA-templated; • negative regulation of intrinsic apoptotic signaling pathway; • negative regulation of apoptotic process; • negative regulation of JNK cascade; • regulation of JNK cascade; • JUN phosphorylation; • negative regulation of JUN kinase activity; • vesicle-mediated transport; • GO:0072468 signal transduction; • positive regulation of MAPK cascade; • positive regulation of JNK cascade; • regulation of CD8-positive, alpha-beta T cell proliferation;
	Sources:Amigo / QuickGO
Orthologau
	9479
	n/a
	ENSG00000121653
	n/a
	Q9UQF2
	n/a
	NM_005456
	n/a
	NP_005447
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAPK8IP1 yw MAPK8IP1 a elwir hefyd yn Mitogen-activated protein kinase 8 interacting protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11p11.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAPK8IP1.

IB1
JIP1
JIP-1
PRKM8IP

Llyfryddiaeth

"JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA). ". Br J Cancer. 2004. PMID 15138488.
"Calcium- and proteasome-dependent degradation of the JNK scaffold protein islet-brain 1. ". J Biol Chem. 2003. PMID 14507925.
"Role of the JNK-interacting protein 1/islet brain 1 in cell degeneration in Alzheimer disease and diabetes. ". Brain Res Bull. 2009. PMID 19616077.
"IB1/JIP-1 controls JNK activation and increased during prostatic LNCaP cells neuroendocrine differentiation. ". Cell Signal. 2005. PMID 15894166.
"The JNK interacting protein JIP-1 and insulin like growth factor II genes are co-expressed in human embryonic tumours.". Anticancer Res. 2005. PMID 15868948.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MAPK8IP1 - Cronfa NCBI

[1]

[2]