MAPT

MAPT
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1I8H, 4GLR, 2ON9, 3OVL, 4E0M, 4E0N, 4E0O, 4FL5, 4NP8, 2MZ7, 4TQE, 4Y5I, 4Y32, 5DMG, 4Y3B, 5HF3, 5E2W, 5E2V
Dynodwyr
Cyfenwau	MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, microtubule associated protein tau, Tau proteins, tau-40
Dynodwyr allanol	OMIM: 157140 HomoloGene: 74962 GeneCards: MAPT
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• apolipoprotein binding; • SH3 domain binding; • tubulin binding; • GO:0001948, GO:0016582 protein binding; • lipoprotein particle binding; • enzyme binding; • DNA binding; • actin binding; • microtubule binding; • dynactin binding; • receptor ligand activity; • protein phosphatase 2A binding; • Hsp90 protein binding; • minor groove of adenine-thymine-rich DNA binding; • double-stranded DNA binding; • single-stranded DNA binding; • RNA binding; • protein kinase binding; • protein-macromolecule adaptor activity; • phosphatidylinositol binding; • identical protein binding; • protein homodimerization activity; • sequence-specific DNA binding; • chaperone binding; • histone-dependent DNA binding; • microtubule lateral binding; • phosphatidylinositol bisphosphate binding;
Cydrannau o'r gell	• cytoplasm; • cell body; • cell projection; • nuclear periphery; • growth cone; • neurofibrillary tangle; • Cellbilen; • tubulin complex; • dendrite; • cytoplasmic ribonucleoprotein granule; • Cytosgerbwd; • cnewyllyn cell; • cytosol; • microtubule; • microtubule associated complex; • bilen; • nuclear speck; • axon; • somatodendritic compartment; • soma; • axon cytoplasm; • extracellular region; • intracellular anatomical structure; • mitocondria; • microtubule cytoskeleton; • axolemma; • neuron projection; • dendritic spine; • main axon; • membrane raft; • glial cell projection;
Prosesau biolegol	• generation of neurons; • regulation of autophagy; • regulation of microtubule polymerization; • positive regulation of microtubule polymerization; • positive regulation of axon extension; • microtubule cytoskeleton organization; • microglial cell activation; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • GO:0072468 signal transduction; • Cof; • negative regulation of mitochondrial membrane potential; • axonal transport of mitochondrion; • cytoplasmic microtubule organization; • neuron projection development; • positive regulation of superoxide anion generation; • negative regulation of kinase activity; • cellular response to heat; • astrocyte activation; • intracellular distribution of mitochondria; • synapse organization; • regulation of calcium-mediated signaling; • protein complex oligomerization; • plus-end-directed organelle transport along microtubule; • regulation of mitochondrial fission; • negative regulation of mitochondrial fission; • axonal transport; • regulation of cellular response to heat; • positive regulation of neuron death; • positive regulation of protein localization to synapse; • neurofibrillary tangle assembly; • negative regulation of establishment of protein localization to mitochondrion; • positive regulation of diacylglycerol kinase activity; • regulation of response to DNA damage stimulus; • internal protein amino acid acetylation; • cell-cell signaling; • response to lead ion; • regulation of signaling receptor activity; • negative regulation of gene expression; • rRNA metabolic process; • central nervous system neuron development; • regulation of microtubule polymerization or depolymerization; • regulation of chromosome organization; • stress granule assembly; • GO:0072353 cellular response to reactive oxygen species; • microtubule polymerization; • regulation of synaptic plasticity; • axon development; • regulation of microtubule cytoskeleton organization; • supramolecular fiber organization; • regulation of long-term synaptic depression; • positive regulation of protein localization; • negative regulation of tubulin deacetylation; • amyloid fibril formation; • cellular response to nerve growth factor stimulus; • cellular response to brain-derived neurotrophic factor stimulus;
	Sources:Amigo / QuickGO
Orthologau
	4137
	n/a
	ENSG00000186868; ENSG00000276155; ENSG00000277956
	n/a
	P10636
	n/a
NM_001123066; NM_001123067; NM_001203251; NM_001203252; NM_005910;
	NM_016834; NM_016835; NM_016841; NM_001377265; NM_001377266; NM_001377267; NM_001377268
	n/a
NP_001116538; NP_001116539; NP_001190180; NP_001190181; NP_005901;
	NP_058518; NP_058519; NP_058525; NP_001364194; NP_001364195; NP_001364196; NP_001364197
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAPT yw MAPT a elwir hefyd yn Microtubule associated protein tau (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q21.31.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAPT.

TAU
MSTD
PPND
DDPAC
MAPTL
MTBT1
MTBT2
FTDP-17
PPP1R103

Llyfryddiaeth

"Increased levels of plasma total tau in adult Down syndrome. ". PLoS One. 2017. PMID 29190730.
"JNK signaling pathway regulates sorbitol-induced Tau proteolysis and apoptosis in SH-SY5Y cells by targeting caspase-3. ". Arch Biochem Biophys. 2017. PMID 29126968.
"Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons. ". Brain. 2017. PMID 29053786.
"Dimerization and Long-Range Repulsion Established by Both Termini of the Microtubule-Associated Protein Tau. ". Biochemistry. 2017. PMID 29039655.
"Isothermal titration calorimetry and vesicle leakage assays highlight the differential behaviors of tau repeat segments upon interaction with anionic lipid membranes.". Biochem Biophys Res Commun. 2017. PMID 28986260.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MAPT - Cronfa NCBI

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[2]