MBD4

MBD4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2MOE, 3IHO, 4DK9, 4E9E, 4E9F, 4E9G, 4E9H, 4EA4, 4EA5, 4LG7, 4OFA, 4OFE, 4OFH, 5CHZ
Dynodwyr
Cyfenwau	MBD4, MED1, methyl-CpG binding domain 4, DNA glycosylase
Dynodwyr allanol	OMIM: 603574 HomoloGene: 2916 GeneCards: MBD4
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • satellite DNA binding; • endodeoxyribonuclease activity; • GO:0001948, GO:0016582 protein binding; • catalytic activity; • hydrolase activity; • pyrimidine-specific mismatch base pair DNA N-glycosylase activity; • DNA N-glycosylase activity;
Cydrannau o'r gell	• chromatin; • cnewyllyn cell; • nucleoplasm; • nuclear speck;
Prosesau biolegol	• response to estradiol; • depyrimidination; • GO:0100026 DNA repair; • cellular response to DNA damage stimulus; • response to radiation;
	Sources:Amigo / QuickGO
Orthologau
	8930
	n/a
	ENSG00000129071
	n/a
	O95243
	n/a
	NM_001276270; NM_001276271; NM_001276272; NM_001276273; NM_003925
	n/a
	NP_001263199; NP_001263200; NP_001263201; NP_001263202; NP_003916
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MBD4 yw MBD4 a elwir hefyd yn Methyl-CpG binding domain 4, DNA glycosylase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q21.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MBD4.

MED1

Llyfryddiaeth

"Crystal structure of human methyl-binding domain IV glycosylase bound to abasic DNA. ". J Mol Biol. 2012. PMID 22560993.
"Crystal structure of the mismatch-specific thymine glycosylase domain of human methyl-CpG-binding protein MBD4. ". Biochem Biophys Res Commun. 2011. PMID 21820404.
"Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis. ". Oncotarget. 2015. PMID 26503472.
"The MBD4 Glu346Lys polymorphism is associated with the risk of cervical cancer in a Chinese population. ". Int J Gynecol Cancer. 2012. PMID 23027038.
"Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.". Nucleic Acids Res. 2012. PMID 22848106.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MBD4 - Cronfa NCBI

[1]

[2]