MBL2

MBL2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1HUP
Dynodwyr
Cyfenwau	MBL2, COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, MBPD, mannose binding lectin 2
Dynodwyr allanol	OMIM: 154545 HomoloGene: 110436 GeneCards: MBL2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • calcium-dependent protein binding; • GO:0001948, GO:0016582 protein binding; • mannose binding; • signaling receptor binding; • carbohydrate binding; • serine-type endopeptidase activity;
Cydrannau o'r gell	• collagen; • extracellular region; • cell surface; • extracellular space; • GO:0005578 extracellular matrix; • collagen-containing extracellular matrix;
Prosesau biolegol	• complement activation, lectin pathway; • positive regulation of phagocytosis; • killing by host of symbiont cells; • negative regulation of viral process; • immune system process; • complement activation; • GO:0001306 response to oxidative stress; • acute-phase response; • defense response to bacterium; • complement activation, classical pathway; • opsonization; • GO:0051637 defense response to Gram-positive bacterium; • innate immune response; • proteolysis; • growth plate cartilage chondrocyte morphogenesis;
	Sources:Amigo / QuickGO
Orthologau
	4153
	n/a
	ENSG00000165471
	n/a
	P11226
	n/a
	NM_000242; NM_001378373; NM_001378374
	n/a
	NP_000233; NP_001365302; NP_001365303
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MBL2 yw MBL2 a elwir hefyd yn Mannose binding lectin 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10q21.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MBL2.

MBL
MBP
MBP1
MBPD
MBL2D
MBP-C
COLEC1
HSMBPC

Llyfryddiaeth

"The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants. ". PLoS One. 2017. PMID 28558032.
"HBV Viral Load and Liver Enzyme Levels May Be Associated with the Wild MBL2AA Genotype. ". Mediators Inflamm. 2017. PMID 28408790.
"High rate of in-stent restenosis after coronary intervention in carriers of the mutant mannose-binding lectin allele. ". BMC Cardiovasc Disord. 2017. PMID 28056798.
"Mannose-binding lectin 2 (Mbl2) gene polymorphisms are related to protein plasma levels, but not to heart disease and infection by Chlamydia. ". Braz J Med Biol Res. 2016. PMID 27982280.
"Mannose-Binding Lectin Deficiency in Brazilian Patients with Spondyloarthritis.". Immunol Invest. 2017. PMID 27911110.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MBL2 - Cronfa NCBI

[1]

[2]