MBNL1

MBNL1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3D2N, 3D2Q, 3D2S
Dynodwyr
Cyfenwau	MBNL1, EXP, EXP35, EXP40, EXP42, MBNL, muscleblind like splicing regulator 1
Dynodwyr allanol	OMIM: 606516 HomoloGene: 23186 GeneCards: MBNL1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• regulatory region RNA binding; • double-stranded RNA binding; • GO:0001948, GO:0016582 protein binding; • metal ion binding; • RNA binding;
Cydrannau o'r gell	• cytoplasm; • centrosome; • cytoplasmic stress granule; • cnewyllyn cell; • nucleoplasm; • cytosol;
Prosesau biolegol	• mRNA processing; • regulation of RNA splicing; • myoblast differentiation; • in utero embryonic development; • embryonic limb morphogenesis; • RNA splicing; • nervous system development; • regulation of alternative mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologau
	4154
	n/a
	ENSG00000152601
	n/a
	Q9NR56; Q86VM6
	n/a
NM_001314057; NM_021038; NM_207292; NM_207293; NM_207294;
	NM_207295; NM_207296; NM_207297; NM_001363870
	n/a
NP_001300986; NP_066368; NP_997175; NP_997176; NP_997177;
	NP_997178; NP_997179; NP_997180; NP_001350799; NP_001363747; NP_001363748; NP_001363749; NP_001363750; NP_001363751; NP_001363752; NP_001363753; NP_001363754; NP_001363755; NP_001363756; NP_001363757; NP_001363758; NP_001363759; NP_001363760; NP_001363761; NP_001363762; NP_001363763; NP_001363764; NP_001363765; NP_001363766; NP_001363767; NP_001363768; NP_001363769; NP_001363770; NP_001363771; NP_001363772; NP_001363773; NP_001363774; NP_001363775; NP_001363776; NP_001363777; NP_001363778; NP_001363780; NP_001363782; NP_001300986.1; NP_997178.1; NP_997179.1; NP_997180.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MBNL1 yw MBNL1 a elwir hefyd yn MBNL1 protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3q25.1-q25.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MBNL1.

EXP
MBNL

Llyfryddiaeth

"Muscleblind-like 1 suppresses breast cancer metastatic colonization and stabilizes metastasis suppressor transcripts. ". Genes Dev. 2016. PMID 26883358.
"Dissecting domains necessary for activation and repression of splicing by Muscleblind-like protein 1. ". BMC Mol Biol. 2013. PMID 24373687.
"Transcriptionally correlated subcellular dynamics of MBNL1 during lens development and their implication for the molecular pathology of myotonic dystrophy type 1. ". Biochem J. 2014. PMID 24354850.
"Muscleblind-like1 undergoes ectopic relocation in the nuclei of skeletal muscles in myotonic dystrophy and sarcopenia. ". Eur J Histochem. 2013. PMID 23807294.
"RNA splicing is responsive to MBNL1 dose.". PLoS One. 2012. PMID 23166594.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MBNL1 - Cronfa NCBI

[1]

[2]