MC4R

MC4R
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2IQP, 2IQR, 2IQS, 2IQU, 2IQV, 2IQW
Dynodwyr
Cyfenwau	MC4R, Melanocortin 4 receptor, BMIQ20
Dynodwyr allanol	OMIM: 155541 HomoloGene: 4320 GeneCards: MC4R
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• G protein-coupled receptor activity; • signal transducer activity; • peptide hormone binding; • melanocyte-stimulating hormone receptor activity; • GO:0001948, GO:0016582 protein binding; • melanocortin receptor activity; • ubiquitin protein ligase binding; • neuropeptide binding; • hormone binding;
Cydrannau o'r gell	• integral component of membrane; • bilen; • Cellbilen; • cnewyllyn cell;
Prosesau biolegol	• regulation of grooming behavior; • adenylate cyclase-modulating G protein-coupled receptor signaling pathway; • insulin secretion; • regulation of feeding behavior; • positive regulation of bone resorption; • diet induced thermogenesis; • response to insulin; • feeding behavior; • negative regulation of feeding behavior; • energy reserve metabolic process; • regulation of metabolic process; • GO:0072468 signal transduction; • G protein-coupled receptor signaling pathway; • adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	4160
	n/a
	ENSG00000166603
	n/a
	P32245
	n/a
	NM_005912
	n/a
	NP_005903
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MC4R yw MC4R a elwir hefyd yn Melanocortin 4 receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 18, band 18q21.32.^[2]

Llyfryddiaeth

"Rs12970134 near MC4R is associated with appetite and beverage intake in overweight and obese children: A family-based association study in Chinese population. ". PLoS One. 2017. PMID 28520814.
"Searching for the relationship between the parameters of metabolic syndrome and the rs17782313 (T>C) polymorphism of the MC4Rgene in postmenopausal women. ". Clin Interv Aging. 2017. PMID 28356726.
"Physical Activity and Sedentary Behaviors Modify the Association between Melanocortin 4 Receptor Gene Variant and Obesity in Chinese Children and Adolescents. ". PLoS One. 2017. PMID 28081251.
"Association of the melanocortin 4 receptor gene rs17782313 polymorphism with rewarding value of food and eating behavior in Chilean children. ". J Physiol Biochem. 2017. PMID 27730429.
"A Common Variant and the Transcript Levels of MC4R Gene Are Associated With Adiposity in Children: The IDEFICS Study.". J Clin Endocrinol Metab. 2016. PMID 27583473.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MC4R - Cronfa NCBI

[1]

[2]