MDK

MDK
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1MKC, 1MKN
Dynodwyr
Cyfenwau	MDK, ARAP, MK, NEGF2, midkine (neurite growth-promoting factor 2), midkine
Dynodwyr allanol	OMIM: 162096 HomoloGene: 1792 GeneCards: MDK
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• growth factor activity; • heparin binding;
Cydrannau o'r gell	• cytoplasm; • cell projection; • extracellular region; • collagen-containing extracellular matrix;
Prosesau biolegol	• Notch signaling pathway; • GO:1904089 negative regulation of neuron apoptotic process; • regulation of behavior; • cerebellar granular layer development; • dentate gyrus development; • response to glucocorticoid; • behavioral fear response; • nervous system development; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • multicellular organism development; • defecation; • short-term memory; • cerebral cortex development; • response to hormone; • cell migration; • hippocampus development; • positive regulation of cell division; • GO:0072468 signal transduction; • negative regulation of neuron death; • response to wounding; • adrenal gland development; • cell differentiation; • regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologau
	4192
	n/a
	ENSG00000110492
	n/a
	P21741
	n/a
NM_001012333; NM_001012334; NM_001270550; NM_001270551; NM_001270552;
	NM_002391
	n/a
NP_001012333; NP_001012334; NP_001257479; NP_001257480; NP_001257481;
	NP_002382
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MDK yw MDK a elwir hefyd yn Midkine (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11p11.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MDK.

MK
ARAP
NEGF2

Llyfryddiaeth

"Diagnostic accuracy of ELISA for detecting serum Midkine in cancer patients. ". PLoS One. 2017. PMID 28686647.
"Midkine is up-regulated in both cancerous and inflamed bowel, reflecting lymph node metastasis in colorectal cancer and clinical activity of ulcerative colitis. ". Cytokine. 2017. PMID 27692729.
"Circulating midkine in children with Henoch-Schönlein purpura: Clinical implications. ". Int Immunopharmacol. 2016. PMID 27497193.
"The role of midkine in the inflammatory process and its correlation with other inflammatory markers in renal transplant recipients. ". Int J Artif Organs. 2016. PMID 27470002.
"Serum midkine as a biomarker for malignancy, prognosis, and chemosensitivity in head and neck squamous cell carcinoma.". Cancer Med. 2016. PMID 26798989.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MDK - Cronfa NCBI

[1]

[2]