METAP1

METAP1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2B3H, 2B3K, 2B3L, 2G6P, 2GZ5, 2NQ6, 2NQ7, 4FLI, 4FLJ, 4FLK, 4FLL, 4HXX, 4IKR, 4IKS, 4IKT, 4IKU, 4IU6, 4U1B, 4U69, 4U6C, 4U6E, 4U6J, 4U6W, 4U6Z, 4U70, 4U71, 4U73, 4U75, 4U76
Dynodwyr
Cyfenwau	METAP1, MAP1A, MetAP1A, methionyl aminopeptidase 1
Dynodwyr allanol	OMIM: 610151 HomoloGene: 6488 GeneCards: METAP1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0070122 peptidase activity; • aminopeptidase activity; • metalloexopeptidase activity; • hydrolase activity; • metal ion binding;
Cydrannau o'r gell	• cytosol; • cytoplasm;
Prosesau biolegol	• peptidyl-methionine modification; • platelet aggregation; • N-terminal protein amino acid modification; • regulation of translation; • proteolysis; • regulation of rhodopsin mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	23173
	n/a
	ENSG00000164024
	n/a
	P53582
	n/a
	NM_015143
	n/a
	NP_055958
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn METAP1 yw METAP1 a elwir hefyd yn Methionyl aminopeptidase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q23.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn METAP1.

MAP1A
MetAP1A

Llyfryddiaeth

"Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases. ". Biochemistry. 2010. PMID 20521764.
"Kinetic and mutational studies of the number of interacting divalent cations required by bacterial and human methionine aminopeptidases. ". Biochemistry. 2007. PMID 17929833.
"Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. ". Proc Natl Acad Sci U S A. 2006. PMID 17114291.
"Functional expression of human methionine aminopeptidase type 1 in Saccharomyces cerevisiae. ". Protein Pept Lett. 2002. PMID 12144506.
"Identification, biochemical and structural evaluation of species-specific inhibitors against type I methionine aminopeptidases.". J Med Chem. 2013. PMID 23767698.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] METAP1 - Cronfa NCBI

[1]

[2]