MKNK2

MKNK2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2AC3, 2AC5
Dynodwyr
Cyfenwau	MKNK2, GPRK7, MNK2, MAP kinase interacting serine/threonine kinase 2, MAPK interacting serine/threonine kinase 2
Dynodwyr allanol	OMIM: 605069 HomoloGene: 49674 GeneCards: MKNK2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • protein kinase activity; • calcium-dependent protein serine/threonine kinase activity; • metal ion binding; • calmodulin binding; • kinase activity; • protein serine/threonine kinase activity; • GO:0001948, GO:0016582 protein binding; • calmodulin-dependent protein kinase activity; • ATP binding;
Cydrannau o'r gell	• cytoplasm; • PML body; • nuclear body; • cnewyllyn cell; • nucleoplasm;
Prosesau biolegol	• GO:0007243 intracellular signal transduction; • phosphorylation; • protein phosphorylation; • cell surface receptor signaling pathway; • cellular response to arsenic-containing substance; • GO:0035404 peptidyl-serine phosphorylation; • extrinsic apoptotic signaling pathway in absence of ligand; • protein autophosphorylation; • regulation of translation; • GO:0097285 apoptotic process; • hemopoiesis;
	Sources:Amigo / QuickGO
Orthologau
	2872
	n/a
	ENSG00000099875
	n/a
	Q9HBH9
	n/a
	NM_199054; NM_017572
	n/a
	NP_060042; NP_951009
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MKNK2 yw MKNK2 a elwir hefyd yn MAP kinase-interacting serine/threonine-protein kinase 2 a MAP kinase interacting serine/threonine kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19p13.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MKNK2.

MNK2
GPRK7

Llyfryddiaeth

"The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases). ". Front Biosci. 2008. PMID 18508592.
"Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site. ". Structure. 2005. PMID 16216586.
"Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells. ". Oncotarget. 2014. PMID 25193863.
"Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway. ". Oncogene. 2013. PMID 22797067.
"Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2.". J Biol Chem. 2008. PMID 18299328.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MKNK2 - Cronfa NCBI

[1]

[2]