MMP13

MMP13
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1EUB, 1FLS, 1FM1, 1PEX, 1XUC, 1XUD, 1XUR, 1YOU, 1ZTQ, 2D1N, 2E2D, 2OW9, 2OZR, 2PJT, 2YIG, 3ELM, 3I7G, 3I7I, 3KEC, 3KEJ, 3KEK, 3KRY, 3LJZ, 3O2X, 3TVC, 3WV1, 3WV2, 3WV3, 3ZXH, 456C, 4A7B, 4FU4, 4FVL, 4G0D, 4JP4, 4JPA, 4L19, 5BOT, 5BOY, 5BPA, 830C
Dynodwyr
Cyfenwau	MMP13, CLG3, MANDP1, MMP-13, Matrix metallopeptidase 13, MDST
Dynodwyr allanol	OMIM: 600108 HomoloGene: 20548 GeneCards: MMP13
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• collagen binding; • zinc ion binding; • metal ion binding; • GO:0070122 peptidase activity; • metalloendopeptidase activity; • hydrolase activity; • metallopeptidase activity; • serine-type endopeptidase activity; • calcium ion binding;
Cydrannau o'r gell	• GO:0005578 extracellular matrix; • extracellular region; • extracellular space;
Prosesau biolegol	• growth plate cartilage development; • bone mineralization; • bone morphogenesis; • extracellular matrix disassembly; • endochondral ossification; • proteolysis; • cartilage development; • collagen catabolic process; • extracellular matrix organization; • response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologau
	4322
	n/a
	ENSG00000137745
	n/a
	P45452
	n/a
	NM_002427
	n/a
	NP_002418
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MMP13 yw MMP13 a elwir hefyd yn Matrix metallopeptidase 13 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q22.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MMP13.

CLG3
MDST
MANDP1
MMP-13

Llyfryddiaeth

"Posterior tibial tendinopathy associated with matrix metalloproteinase 13 promoter genotype and haplotype. ". J Gene Med. 2016. PMID 27886420.
"Matrix Metalloproteinase-13 - A Potential Biomarker for Detection and Prognostic Assessment of Patients with Esophageal Squamous Cell Carcinoma. ". Asian Pac J Cancer Prev. 2016. PMID 27356690.
"Hyaluronic Acid Suppresses the Expression of Metalloproteinases in Osteoarthritic Cartilage Stimulated Simultaneously by Interleukin 1β and Mechanical Load. ". PLoS One. 2016. PMID 26934732.
"Induction of the Matrix Metalloproteinase 13 Gene in Bronchial Epithelial Cells by Interferon and Identification of its Novel Functional Polymorphism. ". Inflammation. 2016. PMID 26635116.
"Function of sustained released resveratrol on IL-1β-induced hBMSC MMP13 secretion inhibition and chondrogenic differentiation promotion.". J Biomater Appl. 2016. PMID 26526931.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MMP13 - Cronfa NCBI

[1]

[2]