MMP9

MMP9
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1GKC, 1GKD, 1ITV, 1L6J, 2OVX, 2OVZ, 2OW0, 2OW1, 2OW2, 4H1Q, 4H2E, 4H3X, 4H82, 4HMA, 4JIJ, 4JQG, 4WZV, 4XCT, 5CUH, 5I12
Dynodwyr
Cyfenwau	MMP9, CLG4B, GELB, MANDP2, MMP-9, 92 kDa type IV collagenase, 92 kDa gelatinase, gelatinase B, matrix metallopeptidase 9
Dynodwyr allanol	OMIM: 120361 HomoloGene: 3659 GeneCards: MMP9
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• collagen binding; • zinc ion binding; • metal ion binding; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • hydrolase activity; • metallopeptidase activity; • endopeptidase activity; • serine-type endopeptidase activity; • metalloendopeptidase activity;
Cydrannau o'r gell	• GO:0005578 extracellular matrix; • extracellular exosome; • extracellular space; • tertiary granule lumen; • ficolin-1-rich granule lumen; • extracellular region; • collagen-containing extracellular matrix;
Prosesau biolegol	• skeletal system development; • negative regulation of cation channel activity; • positive regulation of protein phosphorylation; • endodermal cell differentiation; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; • ossification; • negative regulation of intrinsic apoptotic signaling pathway; • ephrin receptor signaling pathway; • extracellular matrix disassembly; • negative regulation of apoptotic process; • proteolysis; • macrophage differentiation; • positive regulation of keratinocyte migration; • positive regulation of apoptotic process; • collagen catabolic process; • positive regulation of release of cytochrome c from mitochondria; • positive regulation of receptor binding; • positive regulation of DNA binding; • positive regulation of epidermal growth factor receptor signaling pathway; • embryo implantation; • leukocyte migration; • positive regulation of vascular associated smooth muscle cell proliferation; • extracellular matrix organization; • positive regulation of cell migration; • neutrophil degranulation; • GO:0072353 cellular response to reactive oxygen species; • cellular response to cadmium ion; • cytokine-mediated signaling pathway; • regulation of neuroinflammatory response; • negative regulation of epithelial cell differentiation involved in kidney development; • response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologau
	4318
	n/a
	ENSG00000100985
	n/a
	P14780
	n/a
	NM_004994
	n/a
	NP_004985
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MMP9 yw MMP9 a elwir hefyd yn Matrix metallopeptidase 9 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20q13.12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MMP9.

GELB
CLG4B
MMP-9
MANDP2

Llyfryddiaeth

"Crosstalk Between Histone and DNA Methylation in Regulation of Retinal Matrix Metalloproteinase-9 in Diabetes. ". Invest Ophthalmol Vis Sci. 2017. PMID 29261844.
"MMP9 gene expression regulation by intragenic epigenetic modifications in breast cancer. ". Gene. 2018. PMID 29162512.
"Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation. ". J Biol Chem. 2017. PMID 28860188.
"[The plasma levels and diagnostic utility of matrix metalloproteinase-9 and CA 125 in cervical cancer patients]. ". Pol Merkur Lekarski. 2017. PMID 28805195.
"Serum matrix metalloproteinase-9 levels and prognosis of acute ischemic stroke.". Neurology. 2017. PMID 28747453.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MMP9 - Cronfa NCBI

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[2]