MST1

MST1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2ASU, 4QT8
Dynodwyr
Cyfenwau	MST1, D3F15S2, DNF15S2, HGFL, MSP, NF15S2, macrophage stimulating 1
Dynodwyr allanol	OMIM: 142408 HomoloGene: 7360 GeneCards: MST1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• receptor tyrosine kinase binding; • GO:0001948, GO:0016582 protein binding; • serine-type endopeptidase activity;
Cydrannau o'r gell	• extracellular region; • extracellular space; • collagen-containing extracellular matrix;
Prosesau biolegol	• proteolysis; • regulation of cAMP-dependent protein kinase activity; • hepatocyte growth factor receptor signaling pathway; • negative regulation of gluconeogenesis; • regulation of macrophage chemotaxis; • positive regulation of mammary gland epithelial cell proliferation;
	Sources:Amigo / QuickGO
Orthologau
	4485
	n/a
	ENSG00000173531
	n/a
	P26927
	n/a
NM_020998; NM_001393581; NM_001393582; NM_001393583; NM_001393584;
	NM_001393585
	n/a
	NP_066278
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MST1 yw MST1 a elwir hefyd yn Macrophage stimulating 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3p21.31.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MST1.

MSP
HGFL
NF15S2
D3F15S2
DNF15S2

Llyfryddiaeth

"MST1: a promising therapeutic target to restore functional beta cell mass in diabetes. ". Diabetologia. 2016. PMID 27053234.
"Cell surface marker profiling of human tracheal basal cells reveals distinct subpopulations, identifies MST1/MSP as a mitogenic signal, and identifies new biomarkers for lung squamous cell carcinomas. ". Respir Res. 2014. PMID 25551685.
"The effects of macrophage-stimulating protein on the migration, proliferation, and collagen synthesis of skin fibroblasts in vitro and in vivo. ". Tissue Eng Part A. 2015. PMID 25315688.
"Mammalian sterile-like 1 kinase inhibits TGFβ and EGFâ€‘dependent regulation of invasiveness, migration and proliferation of HEC-1-A endometrial cancer cells. ". Int J Oncol. 2014. PMID 24841766.
"Mst1 overexpression inhibited the growth of human non-small cell lung cancer in vitro and in vivo.". Cancer Gene Ther. 2013. PMID 23928732.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MST1 - Cronfa NCBI

[1]

[2]