MUTYH

MUTYH
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1X51, 3N5N
Dynodwyr
Cyfenwau	MUTYH, MYH, mutY DNA glycosylase, mutY homolog (E. coli)
Dynodwyr allanol	OMIM: 604933 HomoloGene: 8156 GeneCards: MUTYH
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• MutSalpha complex binding; • metal ion binding; • hydrolase activity, acting on glycosyl bonds; • hydrolase activity; • catalytic activity; • iron-sulfur cluster binding; • MutLalpha complex binding; • 4 iron, 4 sulfur cluster binding; • MutLbeta complex binding; • MutSbeta complex binding; • GO:0001948, GO:0016582 protein binding; • DNA N-glycosylase activity; • DNA binding; • purine-specific mismatch base pair DNA N-glycosylase activity; • oxidized purine DNA binding; • 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity; • adenine/guanine mispair binding;
Cydrannau o'r gell	• nucleoplasm; • mitocondria; • cnewyllyn cell;
Prosesau biolegol	• GO:0100026 DNA repair; • metabolaeth; • depurination; • cellular response to DNA damage stimulus; • DNA mismatch repair; • base-excision repair;
	Sources:Amigo / QuickGO
Orthologau
	4595
	n/a
	ENSG00000132781
	n/a
	Q9UIF7
	n/a
NM_001048171; NM_001048172; NM_001048173; NM_001048174; NM_001128425;
	NM_001293190; NM_001293191; NM_001293192; NM_001293195; NM_001293196; NM_012222; NM_001350650; NM_001350651
	n/a
NP_001041636; NP_001041637; NP_001041638; NP_001041639; NP_001121897;
	NP_001280119; NP_001280120; NP_001280121; NP_001280124; NP_001280125; NP_036354; NP_001337579; NP_001337580; NP_001280121.1; NP_001280125.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MUTYH yw MUTYH a elwir hefyd yn Adenine DNA glycosylase a MutY homolog (E. coli), isoform CRA_f (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p34.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MUTYH.

MYH

Llyfryddiaeth

"Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYH. ". Mol Cell. 2017. PMID 29149600.
"Adrenal Lesions in Patients With (Attenuated) Familial Adenomatous Polyposis and MUTYH-Associated Polyposis. ". Dis Colon Rectum. 2017. PMID 28891849.
"Cutaneous Sebaceous Lesions in a Patient With MUTYH-Associated Polyposis Mimicking Muir-Torre Syndrome. ". Am J Dermatopathol. 2016. PMID 27870730.
"Type and frequency of MUTYH variants in Italian patients with suspected MAP: a retrospective multicenter study. ". J Hum Genet. 2017. PMID 27829682.
"Association of monoallelic MUTYH mutation among Egyptian patients with colorectal cancer.". Fam Cancer. 2017. PMID 27631816.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MUTYH - Cronfa NCBI

[1]

[2]