MYLK

MYLK
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2CQV, 2K0F, 2YR3
Dynodwyr
Cyfenwau	MYLK, AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK, myosin light chain kinase, MMIHS, MMIHS1, MYLK-L
Dynodwyr allanol	OMIM: 600922 HomoloGene: 14202 GeneCards: MYLK
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • protein kinase activity; • metal ion binding; • calmodulin binding; • myosin light chain kinase activity; • kinase activity; • protein serine/threonine kinase activity; • GO:0001948, GO:0016582 protein binding; • actin binding; • ATP binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • cell projection; • stress fiber; • cleavage furrow; • Cytosgerbwd; • lamellipodium; • Cellbilen; • actin cytoskeleton;
Prosesau biolegol	• smooth muscle contraction; • muscle contraction; • phosphorylation; • tonic smooth muscle contraction; • positive regulation of cell migration; • positive regulation of wound healing; • bleb assembly; • cellular hypotonic response; • protein phosphorylation; • aorta smooth muscle tissue morphogenesis; • positive regulation of calcium ion transport;
	Sources:Amigo / QuickGO
Orthologau
	4638
	n/a
	ENSG00000065534
	n/a
	Q15746
	n/a
NM_001321309; NM_005965; NM_053025; NM_053026; NM_053027;
	NM_053028; NM_053029; NM_053030; NM_053031; NM_053032
	n/a
NP_001308238; NP_444253; NP_444254; NP_444255; NP_444256;
	NP_444259; NP_444260
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MYLK yw MYLK a elwir hefyd yn Myosin light chain kinase, smooth muscle a Myosin light chain kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q21.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MYLK.

KRP
AAT7
MLCK
MLCK1
MYLK1
smMLCK
MLCK108
MLCK210
MSTP083

Llyfryddiaeth

"Loss-of-Function Variants in MYLK Cause Recessive Megacystis Microcolon Intestinal Hypoperistalsis Syndrome. ". Am J Hum Genet. 2017. PMID 28602422.
"Myosin Light Chain Kinase MYLK1: Anatomy, Interactions, Functions, and Regulation. ". Biochemistry (Mosc). 2016. PMID 28260490.
"A novel variant in MYLK causes thoracic aortic dissections: genotypic and phenotypic description. ". BMC Med Genet. 2016. PMID 27586135.
"Epigenetic contribution of the myosin light chain kinase gene to the risk for acute respiratory distress syndrome. ". Transl Res. 2017. PMID 27543902.
"Mechanical Stress and Single Nucleotide Variants Regulate Alternative Splicing of the MYLK Gene.". Am J Respir Cell Mol Biol. 2017. PMID 27529643.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MYLK - Cronfa NCBI

[1]

[2]