NEDD4

NEDD4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2KPZ, 2KQ0, 2M3O, 2XBB, 2XBF, 3B7Y, 4BBN, 4BE8, 4N7F, 4N7H, 5C91, 5AHT, 5C7J
Dynodwyr
Cyfenwau	NEDD4, NEDD4-1, RPF1, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase, NEDD4 E3 ubiquitin protein ligase
Dynodwyr allanol	OMIM: 602278 HomoloGene: 136740 GeneCards: NEDD4
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein domain specific binding; • GO:0050372 ubiquitin-protein transferase activity; • sodium channel inhibitor activity; • beta-2 adrenergic receptor binding; • ubiquitin binding; • GO:0001948, GO:0016582 protein binding; • RNA polymerase binding; • proline-rich region binding; • phosphoserine residue binding; • phosphothreonine residue binding; • ionotropic glutamate receptor binding; • transferase activity; • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • Golgi apparatus; • bilen; • ubiquitin ligase complex; • Cellbilen; • apicolateral plasma membrane; • cell cortex; • perinuclear region of cytoplasm; • chromatin; • extracellular exosome; • dendritic spine; • glutamatergic synapse; • postsynaptic cytosol;
Prosesau biolegol	• protein targeting to lysosome; • adaptive immune response; • GO:1903364 positive regulation of protein catabolic process; • blood vessel morphogenesis; • negative regulation of sodium ion transport; • cellular response to UV; • endocardial cushion development; • negative regulation of vascular endothelial growth factor receptor signaling pathway; • protein K63-linked ubiquitination; • regulation of membrane potential; • negative regulation of sodium ion transmembrane transporter activity; • regulation of ion transmembrane transport; • negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; • outflow tract morphogenesis; • receptor internalization; • GO:1901227 negative regulation of transcription by RNA polymerase II; • protein monoubiquitination; • receptor catabolic process; • nervous system development; • regulation of dendrite morphogenesis; • response to calcium ion; • positive regulation of nucleocytoplasmic transport; • neuromuscular junction development; • protein ubiquitination; • regulation of potassium ion transmembrane transporter activity; • lysosomal transport; • ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; • positive regulation of phosphatidylinositol 3-kinase signaling; • progesterone receptor signaling pathway; • GO:0022415 viral process; • neuron projection development; • GO:1904739 regulation of synapse organization; • T cell activation; • regulation of macroautophagy; • glucocorticoid receptor signaling pathway; • protein polyubiquitination; • ubiquitin-dependent protein catabolic process; • proteasome-mediated ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologau
	4734
	n/a
	ENSG00000069869
	n/a
	P46934
	n/a
NM_001284338; NM_001284339; NM_001284340; NM_006154; NM_198400;
	NM_001329212
	n/a
NP_001271267; NP_001271268; NP_001271269; NP_001316141; NP_006145;
	NP_940682
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NEDD4 yw NEDD4 a elwir hefyd yn E3 ubiquitin-protein ligase NEDD4 a Neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q21.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NEDD4.

RPF1
NEDD4-1

Llyfryddiaeth

"The E3 ubiquitin ligase NEDD4 is translationally upregulated and facilitates pancreatic cancer. ". Oncotarget. 2017. PMID 28423617.
"NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt signaling. ". Gynecol Oncol. 2015. PMID 26193427.
"[Association of NEDD4 gene polymorphisms with schizophrenia and its clinical characteristics in Chinese Han population]. ". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015. PMID 26037357.
"A novel small-form NEDD4 regulates cell invasiveness and apoptosis to promote tumor metastasis. ". Oncotarget. 2015. PMID 25823820.
"NEDD4: The founding member of a family of ubiquitin-protein ligases.". Gene. 2015. PMID 25527121.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] NEDD4 - Cronfa NCBI

[1]

[2]