NEO1

NEO1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1X5F, 1X5G, 1X5H, 1X5I, 1X5J, 1X5K, 3P4L, 4UI2
Dynodwyr
Cyfenwau	NEO1, IGDCC2, NGN, NTN1R2, neogenin 1
Dynodwyr allanol	OMIM: 601907 HomoloGene: 1870 GeneCards: NEO1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• co-receptor binding; • GO:0001948, GO:0016582 protein binding; • signaling receptor activity;
Cydrannau o'r gell	• integral component of membrane; • plasma membrane protein complex; • Cellbilen; • Golgi apparatus; • integral component of plasma membrane; • bilen; • nucleoplasm;
Prosesau biolegol	• positive regulation of BMP signaling pathway; • iron ion homeostasis; • cell adhesion; • nervous system development; • axon guidance; • GO:0072468 signal transduction;
	Sources:Amigo / QuickGO
Orthologau
	4756
	n/a
	ENSG00000067141
	n/a
	Q92859
	n/a
	NM_001172623; NM_001172624; NM_002499
	n/a
	NP_001166094; NP_001166095; NP_002490
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NEO1 yw NEO1 a elwir hefyd yn Neogenin 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q24.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NEO1.

NGN
IGDCC2
NTN1R2

Llyfryddiaeth

"Neogenin, Defined as a GD3-associated Molecule by Enzyme-mediated Activation of Radical Sources, Confers Malignant Properties via Intracytoplasmic Domain in Melanoma Cells. ". J Biol Chem. 2016. PMID 27288875.
"Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension. ". Nat Commun. 2016. PMID 27029596.
"Unmasking a novel disease gene NEO1 associated with autism spectrum disorders by a hemizygous deletion on chromosome 15 and a functional polymorphism. ". Behav Brain Res. 2016. PMID 26518331.
"Overexpression of neogenin inhibits cell proliferation and induces apoptosis in human MDA-MB-231 breast carcinoma cells. ". Oncol Rep. 2015. PMID 25998984.
"Neogenin expression is inversely associated with breast cancer grade in ex vivo.". World J Surg Oncol. 2014. PMID 25416629.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] NEO1 - Cronfa NCBI

[1]

[2]