NLGN4X

NLGN4X
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2WQZ, 2XB6, 3BE8
Dynodwyr
Cyfenwau	NLGN4X, ASPGX2, AUTSX2, HLNX, HNL4X, NLGN4, neuroligin 4, X-linked, neuroligin 4 X-linked
Dynodwyr allanol	OMIM: 300427 HomoloGene: 136297 GeneCards: NLGN4X
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein homodimerization activity; • scaffold protein binding; • GO:0004091 carboxylic ester hydrolase activity; • neurexin family protein binding; • GO:0001948, GO:0016582 protein binding; • chloride ion binding; • cell adhesion molecule binding; • signaling receptor activity;
Cydrannau o'r gell	• integral component of membrane; • postsynaptic membrane; • bilen; • GO:0097483, GO:0097481 postsynaptic density; • synapse; • integral component of plasma membrane; • excitatory synapse; • cell surface; • cell junction; • dendrite; • Cellbilen; • intracellular anatomical structure; • spanning component of membrane; • presynapse; • symmetric, GABA-ergic, inhibitory synapse; • asymmetric, glutamatergic, excitatory synapse;
Prosesau biolegol	• cell-cell junction organization; • organ growth; • neuron cell-cell adhesion; • brainstem development; • synapse organization; • learning; • cerebellum development; • negative regulation of excitatory postsynaptic potential; • presynaptic membrane assembly; • vocalization behavior; • adult behavior; • cell adhesion; • neuron differentiation; • social behavior; • synaptic vesicle endocytosis; • postsynaptic membrane assembly; • modulation of chemical synaptic transmission; • presynapse assembly;
	Sources:Amigo / QuickGO
Orthologau
	57502
	n/a
	ENSG00000146938
	n/a
	Q8N0W4
	n/a
	NM_001282145; NM_001282146; NM_020742; NM_181332
	n/a
	NP_001269074; NP_001269075; NP_065793; NP_851849
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NLGN4X yw NLGN4X a elwir hefyd yn Neuroligin 4, X-linked (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom X dynol, band Xp22.32-p22.31.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NLGN4X.

HLNX
HNL4X
NLGN4
ASPGX2
AUTSX2

Llyfryddiaeth

"Gender differences in cognitive ability associated with genetic variants of NLGN4. ". Neuropsychobiology. 2010. PMID 20714171.
"A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export. ". J Neurosci. 2009. PMID 19726642.
"Neuroligin 4X overexpression in human breast cancer is associated with poor relapse-free survival. ". PLoS One. 2017. PMID 29244827.
"The functional genetic link of NLGN4X knockdown and neurodevelopment in neural stem cells. ". Hum Mol Genet. 2013. PMID 23710042.
"Investigating synapse formation and function using human pluripotent stem cell-derived neurons.". Proc Natl Acad Sci U S A. 2011. PMID 21278334.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] NLGN4X - Cronfa NCBI

[1]

[2]