NR0B2

NR0B2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1YUC, 2Q3Y, 2Z4J, 4DOR, 4ONI
Dynodwyr
Cyfenwau	NR0B2, SHP, SHP1, nuclear receptor subfamily 0 group B member 2
Dynodwyr allanol	OMIM: 604630 HomoloGene: 8030 GeneCards: NR0B2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • protein homodimerization activity; • protein domain specific binding; • steroid hormone receptor activity; • GO:0001948, GO:0016582 protein binding; • GO:0001106 transcription corepressor activity; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0032403 protein-containing complex binding; • transcription factor binding; • retinoic acid receptor binding; • peroxisome proliferator activated receptor binding; • retinoid X receptor binding; • thyroid hormone receptor binding;
Cydrannau o'r gell	• nucleoplasm; • cnewyllyn cell; • cytoplasm; • GO:0009327 protein-containing complex;
Prosesau biolegol	• Notch signaling pathway; • GO:0009373 regulation of transcription, DNA-templated; • cholesterol metabolic process; • GO:1901227 negative regulation of transcription by RNA polymerase II; • response to glucose; • negative regulation of DNA-binding transcription factor activity; • negative regulation of gene expression; • transcription, DNA-templated; • GO:1901313 positive regulation of gene expression; • animal organ regeneration; • transcription initiation from RNA polymerase II promoter; • GO:0045996 negative regulation of transcription, DNA-templated; • positive regulation of insulin secretion; • steroid hormone mediated signaling pathway; • Rhythm circadaidd; • circadian regulation of gene expression; • proses rythmig;
	Sources:Amigo / QuickGO
Orthologau
	8431
	n/a
	ENSG00000131910
	n/a
	Q15466
	n/a
	NM_021969
	n/a
	NP_068804
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NR0B2 yw NR0B2 a elwir hefyd yn Nuclear receptor subfamily 0 group B member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p36.11.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NR0B2.

SHP
SHP1

Llyfryddiaeth

"Small heterodimer partner attenuates profibrogenic features of hepatitis C virus-infected cells. ". Liver Int. 2015. PMID 25976932.
"Loss of the orphan nuclear receptor SHP is more pronounced in fibrolamellar carcinoma than in typical hepatocellular carcinoma. ". PLoS One. 2012. PMID 22292081.
"Insights into the binding mode and mechanism of action of some atypical retinoids as ligands of the small heterodimer partner (SHP). ". J Comput Aided Mol Des. 2010. PMID 20882396.
"Systems-level analysis of gene expression data revealed NR0B2/SHP as potential tumor suppressor in human liver cancer. ". Mol Cells. 2010. PMID 20853064.
"Gender-dependent penetrance of small heterodimer partner (SHP) gene deficiency in overweight/obese Chinese pedigrees.". J Int Med Res. 2010. PMID 20233523.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] NR0B2 - Cronfa NCBI

[1]

[2]