NR1D1

NR1D1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1A6Y, 1GA5, 1HLZ, 3N00
Dynodwyr
Cyfenwau	NR1D1, EAR1, THRA1, THRAL, ear-1, hRev, nuclear receptor subfamily 1 group D member 1, REVERBA, REVERBalpha
Dynodwyr allanol	OMIM: 602408 HomoloGene: 23324 GeneCards: NR1D1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001106 transcription corepressor activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • steroid hormone receptor activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • core promoter sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • heme binding • transcription corepressor binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • E-box binding • GO:0000975 transcription cis-regulatory region binding • transcription factor binding • nuclear receptor coactivator activity • signaling receptor activity Cydrannau o'r gell • cytoplasm • cell projection • dendritic spine • nucleoplasm • dendrite • cnewyllyn cell • nuclear body • RNA polymerase II transcription regulator complex Prosesau biolegol • cell differentiation • regulation of insulin secretion involved in cellular response to glucose stimulus • GO:0009373 regulation of transcription, DNA-templated • proses rythmig • circadian temperature homeostasis • positive regulation of bile acid biosynthetic process • GO:1901227 negative regulation of transcription by RNA polymerase II • circadian regulation of gene expression • regulation of fat cell differentiation • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • regulation of lipid metabolic process • glycogen biosynthetic process • regulation of circadian rhythm • Rhythm circadaidd • proteasomal protein catabolic process • transcription initiation from RNA polymerase II promoter • response to leptin • GO:0045996 negative regulation of transcription, DNA-templated • cellular response to lipopolysaccharide • regulation of type B pancreatic cell proliferation • negative regulation of toll-like receptor 4 signaling pathway • steroid hormone mediated signaling pathway • intracellular receptor signaling pathway • cholesterol homeostasis • multicellular organism development • hormone-mediated signaling pathway • response to lipid • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of cold-induced thermogenesis • protein destabilization • regulation of circadian sleep/wake cycle • negative regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of inflammatory response • negative regulation of astrocyte activation • cellular response to interleukin-1 • cellular response to tumor necrosis factor • negative regulation of neuroinflammatory response • negative regulation of microglial cell activation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9572	n/a
Ensembl	ENSG00000126368	n/a
UniProt	P20393	n/a
RefSeq (mRNA)	NM_021724	n/a
RefSeq (protein)	NP_068370	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NR1D1 yw NR1D1 a elwir hefyd yn Nuclear receptor subfamily 1 group D member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q21.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NR1D1.

• EAR1
• hRev
• THRA1
• THRAL
• ear-1

Llyfryddiaeth

• "NR1D1 Recruitment to Sites of DNA Damage Inhibits Repair and Is Associated with Chemosensitivity of Breast Cancer. ". Cancer Res. 2017. PMID 28249904.
• "Molecular mechanisms of transcriptional control by Rev-erbα: An energetic foundation for reconciling structure and binding with biological function. ". Protein Sci. 2015. PMID 25969949.
• "Associations between polymorphisms in the NR1D1 gene encoding for nuclear receptor REV-ERBα and circadian typologies. ". Chronobiol Int. 2015. PMID 25798852.
• "REV-ERB ALPHA polymorphism is associated with obesity in the Spanish obese male population. ". PLoS One. 2014. PMID 25089907.
• "RevErbα preferentially deforms DNA by induced fit.". Chembiochem. 2014. PMID 24677802.

Cyfeiriadau

1. "Human PubMed Reference:".
2. NR1D1 - Cronfa NCBI