NR1D2

NR1D2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4N73, 2V0V, 2V7C, 3CQV
Dynodwyr
Cyfenwau	NR1D2, BD73, EAR-1R, RVR, nuclear receptor subfamily 1 group D member 2, REVERBB, REVERBbeta
Dynodwyr allanol	OMIM: 602304 HomoloGene: 3763 GeneCards: NR1D2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • zinc ion binding; • metal ion binding; • steroid hormone receptor activity; • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity; • core promoter sequence-specific DNA binding; • GO:0001948, GO:0016582 protein binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0001158 cis-regulatory region sequence-specific DNA binding; • GO:0000975 transcription cis-regulatory region binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • transcription factor binding; • nuclear receptor coactivator activity; • signaling receptor activity;
Cydrannau o'r gell	• cnewyllyn cell; • nucleoplasm; • RNA polymerase II transcription regulator complex; • cytoplasm;
Prosesau biolegol	• GO:0009373 regulation of transcription, DNA-templated; • regulation of skeletal muscle cell differentiation; • proses rythmig; • transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • regulation of lipid metabolic process; • regulation of circadian rhythm; • regulation of inflammatory response; • lipid homeostasis; • transcription initiation from RNA polymerase II promoter; • GO:0045996 negative regulation of transcription, DNA-templated; • steroid hormone mediated signaling pathway; • intracellular receptor signaling pathway; • GO:1901227 negative regulation of transcription by RNA polymerase II; • energy homeostasis; • multicellular organism development; • hormone-mediated signaling pathway; • cell differentiation; • response to lipid; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • circadian behavior; • negative regulation of inflammatory response;
	Sources:Amigo / QuickGO
Orthologau
	9975
	n/a
	ENSG00000174738
	n/a
	Q14995; Q6NSM0
	n/a
	NM_001145425; NM_005126
	n/a
	NP_001138897; NP_005117
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NR1D2 yw NR1D2 a elwir hefyd yn NR1D2 protein a Nuclear receptor subfamily 1 group D member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p24.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NR1D2.

RVR
BD73
EAR-1R

Llyfryddiaeth

"The heme-regulatory motif of nuclear receptor Rev-erbβ is a key mediator of heme and redox signaling in circadian rhythm maintenance and metabolism. ". J Biol Chem. 2017. PMID 28500133.
"High Affinity Heme Binding to a Heme Regulatory Motif on the Nuclear Receptor Rev-erbβ Leads to Its Degradation and Indirectly Regulates Its Interaction with Nuclear Receptor Corepressor. ". J Biol Chem. 2016. PMID 26670607.
"Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells. ". Biochem Biophys Res Commun. 2016. PMID 26616049.
"Dual inhibition of REV-ERBβ and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells. ". Oncogene. 2015. PMID 25023698.
"Structure of REV-ERBβ ligand-binding domain bound to a porphyrin antagonist.". J Biol Chem. 2014. PMID 24872411.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] NR1D2 - Cronfa NCBI

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