NR3C1

NR3C1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1M2Z, 1NHZ, 1P93, 3BQD, 3CLD, 3E7C, 3H52, 3K22, 3K23, 4CSJ, 4HN5, 4HN6, 4LSJ, 4MDD, 4P6W, 4P6X, 5CBY, 5CBX, 4UDC, 4UDD, 5CBZ, 5CC1, 5EMQ, 5EMC, 5EMP
Dynodwyr
Cyfenwau	NR3C1, GCCR, GCR, GCRST, GR, GRL, nuclear receptor subfamily 3 group C member 1, Glucocorticoid Receptor
Dynodwyr allanol	OMIM: 138040 HomoloGene: 30960 GeneCards: NR3C1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• steroid hormone binding; • DNA binding; • sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • zinc ion binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • glucocorticoid receptor activity; • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity; • metal ion binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • steroid hormone receptor activity; • steroid binding; • GO:0001948, GO:0016582 protein binding; • lipid binding; • RNA binding; • SUMO binding; • Hsp90 protein binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • protein kinase binding;
Cydrannau o'r gell	• cytoplasm; • nucleoplasm; • mitochondrial matrix; • mitocondria; • cnewyllyn cell; • Cytosgerbwd; • spindle; • microtubule organizing center; • cytosol; • nuclear speck; • GO:0009327 protein-containing complex;
Prosesau biolegol	• cellular response to steroid hormone stimulus; • GO:0009373 regulation of transcription, DNA-templated; • glucocorticoid mediated signaling pathway; • transcription by RNA polymerase II; • transcription initiation from RNA polymerase II promoter; • glucocorticoid receptor signaling pathway; • GO:0072468 signal transduction; • steroid hormone mediated signaling pathway; • cell cycle; • Cellraniad; • GO:0097285 apoptotic process; • chromosome segregation; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • cellular response to dexamethasone stimulus; • cellular response to transforming growth factor beta stimulus; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • cellular response to glucocorticoid stimulus; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization; • positive regulation of pri-miRNA transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologau
	2908
	n/a
	ENSG00000113580
	n/a
	P04150; Q3MSN4
	n/a
NM_000176; NM_001018074; NM_001018075; NM_001018076; NM_001018077;
	NM_001020825; NM_001024094; NM_001204258; NM_001204259; NM_001204260; NM_001204261; NM_001204262; NM_001204263; NM_001204264; NM_001204265; NM_001364180; NM_001364181; NM_001364182; NM_001364183; NM_001364184; NM_001364185
	n/a
NP_000167; NP_001018084; NP_001018085; NP_001018086; NP_001018087;
	NP_001018661; NP_001019265; NP_001191187; NP_001191188; NP_001191189; NP_001191190; NP_001191191; NP_001191192; NP_001191193; NP_001191194; NP_001351109; NP_001351110; NP_001351111; NP_001351112; NP_001351113; NP_001351114; NP_000167.1; NP_001018084.1; NP_001018085.1; NP_001018086.1; NP_001018087.1; NP_001018661.1; NP_001019265.1; NP_001191187.1; NP_001191188.1; NP_001191189.1; NP_001191190.1; NP_001191191.1; NP_001191192.1; NP_001191193.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NR3C1 yw NR3C1 a elwir hefyd yn Glucocorticoid receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q31.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NR3C1.

GR
GCR
GRL
GCCR
GCRST

Llyfryddiaeth

"Generating diversity in human glucocorticoid signaling through a racially diverse polymorphism in the beta isoform of the glucocorticoid receptor. ". Lab Invest. 2017. PMID 28759007.
"Glucocorticoid receptor polymorphism in obesity and glucose homeostasis. ". Adv Clin Exp Med. 2017. PMID 28397446.
"Glucocorticoid receptor variants in childhood attention-deficit/hyperactivity disorder and comorbid psychiatric disorders. ". Psychiatry Res. 2016. PMID 27741480.
"Glomerular Glucocorticoid Receptors Expression and Clinicopathological Types of Childhood Nephrotic Syndrome. ". Fetal Pediatr Pathol. 2017. PMID 27690709.
"Medical morbidities and DNA methylation of NR3C1 in preterm infants.". Pediatr Res. 2017. PMID 27653086.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] NR3C1 - Cronfa NCBI

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[2]