NR4A2

NR4A2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1OVL
Dynodwyr
Cyfenwau	NR4A2, HZF-3, NOT, NURR1, RNR1, TINUR, nuclear receptor subfamily 4 group A member 2
Dynodwyr allanol	OMIM: 601828 HomoloGene: 4509 GeneCards: NR4A2
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• retinoid X receptor binding; • protein homodimerization activity; • sequence-specific DNA binding; • beta-catenin binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • steroid hormone receptor activity; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001948, GO:0016582 protein binding; • glucocorticoid receptor binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • zinc ion binding; • metal ion binding; • DNA binding; • protein heterodimerization activity; • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cydrannau o'r gell	• cytoplasm; • cnewyllyn cell; • nucleoplasm; • nuclear speck; • transcription regulator complex;
Prosesau biolegol	• dopaminergic neuron differentiation; • cellular response to oxidative stress; • response to hypoxia; • response to amphetamine; • nervous system development; • neuron maturation; • steroid hormone mediated signaling pathway; • central nervous system projection neuron axonogenesis; • GO:0009373 regulation of transcription, DNA-templated; • central nervous system neuron differentiation; • negative regulation of apoptotic signaling pathway; • cellular response to corticotropin-releasing hormone stimulus; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • regulation of respiratory gaseous exchange; • regulation of dopamine metabolic process; • adult locomotory behavior; • regulation of gene expression; • habenula development; • GO:0048554 positive regulation of catalytic activity; • fat cell differentiation; • post-embryonic development; • dopamine biosynthetic process; • transcription initiation from RNA polymerase II promoter; • GO:1904089 negative regulation of neuron apoptotic process; • canonical Wnt signaling pathway; • general adaptation syndrome; • neuron differentiation; • GO:0072468 signal transduction; • dopamine metabolic process; • transcription, DNA-templated; • intracellular receptor signaling pathway; • neuron migration; • GO:1901227 negative regulation of transcription by RNA polymerase II; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • cellular response to extracellular stimulus; • midbrain dopaminergic neuron differentiation; • gene expression; • transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologau
	4929
	n/a
	ENSG00000153234
	n/a
	P43354
	n/a
	NM_006186; NM_173171; NM_173172; NM_173173
	n/a
	NP_006177; NP_775265; NP_006177.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NR4A2 yw NR4A2 a elwir hefyd yn Nuclear receptor related 1 a Nuclear receptor subfamily 4 group A member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q24.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NR4A2.

NOT
RNR1
HZF-3
NURR1
TINUR

Llyfryddiaeth

"cDNA microarray analysis identifies NR4A2 as a novel molecule involved in the pathogenesis of Sjögren's syndrome. ". Clin Exp Immunol. 2017. PMID 28621822.
"Haploinsufficiency of NR4A2 is associated with a neurodevelopmental phenotype with prominent language impairment. ". Am J Med Genet A. 2017. PMID 28544326.
"Identification of a Binding Site for Unsaturated Fatty Acids in the Orphan Nuclear Receptor Nurr1. ". ACS Chem Biol. 2016. PMID 27128111.
"Role of Nurr1 in the Generation and Differentiation of Dopaminergic Neurons from Stem Cells. ". Neurotox Res. 2016. PMID 26678495.
"Decreased expression levels of Nurr1 are associated with chronic inflammation in patients with type 2 diabetes.". Mol Med Rep. 2015. PMID 26239742.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] NR4A2 - Cronfa NCBI

[1]

[2]