NRP1

NRP1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1KEX, 2QQI, 2QQM, 2QQN, 3I97, 4DEQ, 4RN5, 5C7G
Dynodwyr
Cyfenwau	NRP1, BDCA4, CD304, NP1, NRP, VEGF165R, Neuropilin 1
Dynodwyr allanol	OMIM: 602069 HomoloGene: 2876 GeneCards: NRP1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• heparin binding; • vascular endothelial growth factor binding; • GO:0019974 cytokine binding; • semaphorin receptor activity; • coreceptor activity; • metal ion binding; • vascular endothelial growth factor-activated receptor activity; • growth factor binding; • GO:0001948, GO:0016582 protein binding; • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity; • protein kinase binding;
Cydrannau o'r gell	• cytosol; • bilen; • extracellular region; • semaphorin receptor complex; • cell surface; • sorting endosome; • integral component of membrane; • growth cone; • receptor complex; • Cellbilen; • axon; • soma; • early endosome; • neurofilament; • GO:0016023 cytoplasmic vesicle; • extracellular space; • focal adhesion; • neuron projection; • glutamatergic synapse; • integral component of postsynaptic membrane;
Prosesau biolegol	• GO:1904089 negative regulation of neuron apoptotic process; • facioacoustic ganglion development; • vascular endothelial growth factor signaling pathway; • VEGF-activated neuropilin signaling pathway involved in axon guidance; • toxin transport; • cell migration involved in sprouting angiogenesis; • semaphorin-plexin signaling pathway involved in axon guidance; • positive regulation of retinal ganglion cell axon guidance; • positive regulation of smooth muscle cell migration; • sympathetic neuron projection guidance; • vascular endothelial growth factor receptor signaling pathway; • sensory neuron axon guidance; • angiogenesis; • positive regulation of ERK1 and ERK2 cascade; • animal organ morphogenesis; • protein localization to early endosome; • trigeminal nerve structural organization; • regulation of axon extension involved in axon guidance; • coronary artery morphogenesis; • negative regulation of extrinsic apoptotic signaling pathway; • neuron development; • trigeminal nerve morphogenesis; • angiogenesis involved in coronary vascular morphogenesis; • commissural neuron axon guidance; • negative regulation of axon extension involved in axon guidance; • heart development; • response to wounding; • artery morphogenesis; • positive regulation of peptidyl-tyrosine phosphorylation; • branching involved in blood vessel morphogenesis; • platelet-derived growth factor receptor signaling pathway; • positive chemotaxis; • facial nerve structural organization; • hepatocyte growth factor receptor signaling pathway; • axonal fasciculation; • retina vasculature morphogenesis in camera-type eye; • dorsal root ganglion morphogenesis; • axon extension involved in axon guidance; • sympathetic ganglion development; • cell differentiation; • semaphorin-plexin signaling pathway involved in neuron projection guidance; • cellular response to hepatocyte growth factor stimulus; • dendrite development; • sprouting angiogenesis; • neuron migration; • nervous system development; • regulation of retinal ganglion cell axon guidance; • branchiomotor neuron axon guidance; • gonadotrophin-releasing hormone neuronal migration to the hypothalamus; • negative regulation of axon extension; • retinal ganglion cell axon guidance; • renal artery morphogenesis; • ventral trunk neural crest cell migration; • positive regulation of endothelial cell proliferation; • sympathetic nervous system development; • endothelial tip cell fate specification; • cell-cell signaling; • regulation of vesicle-mediated transport; • trigeminal ganglion development; • positive regulation of cytokine activity; • positive regulation of axon extension involved in axon guidance; • axon guidance; • vestibulocochlear nerve structural organization; • multicellular organism development; • neural crest cell migration involved in autonomic nervous system development; • endothelial cell chemotaxis; • axonogenesis involved in innervation; • dichotomous subdivision of terminal units involved in salivary gland branching; • cellular response to vascular endothelial growth factor stimulus; • motor neuron axon guidance; • nerve development; • cell migration; • sympathetic neuron projection extension; • semaphorin-plexin signaling pathway; • GO:0072468 signal transduction; • otic placode development; • motor neuron migration; • outflow tract septum morphogenesis; • substrate-dependent cell migration, cell extension; • integrin-mediated signaling pathway; • positive regulation of endothelial cell migration; • actin cytoskeleton reorganization; • regulation of Cdc42 protein signal transduction; • substrate adhesion-dependent cell spreading; • neuropilin signaling pathway; • VEGF-activated neuropilin signaling pathway; • positive regulation of phosphorylation; • endothelial cell migration; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • positive regulation of angiogenesis; • positive regulation of filopodium assembly; • positive regulation of stress fiber assembly; • positive regulation of focal adhesion assembly; • positive regulation of cell migration involved in sprouting angiogenesis; • positive regulation of substrate adhesion-dependent cell spreading; • positive regulation of actin cytoskeleton reorganization; • postsynapse organization; • basal dendrite development; • basal dendrite arborization;
	Sources:Amigo / QuickGO
Orthologau
	8829
	n/a
	ENSG00000099250
	n/a
	O14786
	n/a
NM_001024628; NM_001024629; NM_001244972; NM_001244973; NM_003873;
	NM_001330068
	n/a
NP_001019799; NP_001019800; NP_001231901; NP_001231902; NP_001316997;
	NP_003864
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NRP1 yw NRP1 a elwir hefyd yn Neuropilin-1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10p11.22.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NRP1.

NP1
NRP
BDCA4
CD304
VEGF165R

Llyfryddiaeth

"Curcumin-loaded nanoliposomes linked to homing peptides for integrin targeting and neuropilin-1-mediated internalization. ". Pharm Biol. 2017. PMID 27937055.
"A Novel Physiological Glycosaminoglycan-Deficient Splice Variant of Neuropilin-1 Is Anti-Tumorigenic In Vitro and In Vivo. ". PLoS One. 2016. PMID 27798666.
"Neuropilin-1 modulates TGFβ signaling to drive glioblastoma growth and recurrence after anti-angiogenic therapy. ". PLoS One. 2017. PMID 28938007.
"Neuropilin 1 binds PDGF-D and is a co-receptor in PDGF-D-PDGFRβ signaling. ". J Cell Sci. 2017. PMID 28254885.
"Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality.". Oncogene. 2017. PMID 28092670.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] NRP1 - Cronfa NCBI

[1]

[2]