NTF3

NTF3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1B8K, 1BND, 1NT3, 3BUK
Dynodwyr
Cyfenwau	NTF3, HDNF, NGF-2, NGF2, NT-3, NT3, neurotrophin 3
Dynodwyr allanol	OMIM: 162660 HomoloGene: 1896 GeneCards: NTF3
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• neurotrophin p75 receptor binding; • neurotrophin receptor binding; • chemoattractant activity; • growth factor activity; • signaling receptor binding; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• GO:0016023 cytoplasmic vesicle; • extracellular region; • extracellular space; • synaptic vesicle; • axon; • dendrite;
Prosesau biolegol	• regulation of apoptotic process; • GO:1904089 negative regulation of neuron apoptotic process; • regulation of neuron differentiation; • activation of protein kinase B activity; • neuron projection morphogenesis; • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity; • positive regulation of receptor internalization; • transmembrane receptor protein tyrosine kinase signaling pathway; • positive regulation of cell migration; • cell-cell signaling; • positive regulation of peptidyl-serine phosphorylation; • induction of positive chemotaxis; • negative regulation of peptidyl-tyrosine phosphorylation; • positive regulation of cell population proliferation; • positive regulation of peptidyl-tyrosine phosphorylation; • positive regulation of actin cytoskeleton reorganization; • GO:0072468 signal transduction; • positive chemotaxis; • nervous system development; • regulation of signaling receptor activity; • positive regulation of phospholipase C activity; • positive regulation of phosphatidylinositol 3-kinase signaling; • peripheral nervous system development; • Cof; • nerve development; • nerve growth factor signaling pathway; • modulation of chemical synaptic transmission; • positive regulation of neurotrophin TRK receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	4908
	n/a
	ENSG00000185652
	n/a
	P20783
	n/a
	NM_001102654; NM_002527
	n/a
	NP_001096124; NP_002518
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NTF3 yw NTF3 a elwir hefyd yn Neurotrophin 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12p13.31.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NTF3.

NT3
HDNF
NGF2
NT-3
NGF-2

Llyfryddiaeth

"Roles of neurotrophins in skeletal tissue formation and healing. ". J Cell Physiol. 2018. PMID 28370021.
"Polymorphisms of the neurotrophic factor-3 (NTF-3) in Alzheimer's disease: rs6332 associated with onset time and rs6489630 T allele exhibited a protective role. ". J Neurogenet. 2015. PMID 26814132.
"Survival, differentiation, and neuroprotective mechanisms of human stem cells complexed with neurotrophin-3-releasing pharmacologically active microcarriers in an ex vivo model of Parkinson's disease. ". Stem Cells Transl Med. 2015. PMID 25925835.
"Neurotrophin 3 genotype and emotional adverse effects of osmotic-release oral system methylphenidate (OROS-MPH) in children with attention-deficit/hyperactivity disorder. ". J Psychopharmacol. 2014. PMID 23471121.
"Association between neurotrophin-3 polymorphisms and executive function in Japanese patients with amnestic mild cognitive impairment and mild Alzheimer disease.". Dement Geriatr Cogn Disord. 2012. PMID 23075484.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] NTF3 - Cronfa NCBI

[1]

[2]