P4HB

P4HB
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1X5C, 1BJX, 2K18, 4JU5, 4EL1, 3BJ5, 1MEK, 2BJX, 3UEM, 4EKZ
Dynodwyr
Cyfenwau	P4HB, DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB, CLCRP1, prolyl 4-hydroxylase subunit beta
Dynodwyr allanol	OMIM: 176790 HomoloGene: 55495 GeneCards: P4HB
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• isomerase activity; • integrin binding; • GO:0001948, GO:0016582 protein binding; • procollagen-proline 4-dioxygenase activity; • protein heterodimerization activity; • enzyme binding; • RNA binding; • GO:0030508 protein disulfide isomerase activity;
Cydrannau o'r gell	• procollagen-proline 4-dioxygenase complex; • endoplasmic reticulum lumen; • bilen; • focal adhesion; • melanosome; • Cellbilen; • endoplasmic reticulum chaperone complex; • extracellular region; • Reticwlwm endoplasmig; • extracellular exosome; • external side of plasma membrane; • endoplasmic reticulum-Golgi intermediate compartment; • GO:0005578 extracellular matrix;
Prosesau biolegol	• positive regulation of viral entry into host cell; • peptidyl-proline hydroxylation to 4-hydroxy-L-proline; • regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; • cell redox homeostasis; • response to endoplasmic reticulum stress; • cellular response to hypoxia; • protein folding; • chylomicron assembly; • very-low-density lipoprotein particle assembly; • cellular response to oxidative stress; • post-translational protein modification; • interleukin-12-mediated signaling pathway; • interleukin-23-mediated signaling pathway; • cellular response to interleukin-7;
	Sources:Amigo / QuickGO
Orthologau
	5034
	n/a
	ENSG00000185624
	n/a
	P07237
	n/a
	NM_000918
	n/a
	NP_000909
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn P4HB yw P4HB a elwir hefyd yn Prolyl 4-hydroxylase subunit beta a Protein disulfide-isomerase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q25.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn P4HB.

DSI
GIT
PDI
PHDB
PDIA1
PO4DB
PO4HB
PROHB
CLCRP1
ERBA2L
P4Hbeta

Llyfryddiaeth

"Advances in vascular thiol isomerase function.". Opin Hematol. 2017. PMID 28598864.
"Kinetic-based trapping by intervening sequence variants of the active sites of protein-disulfide isomerase identifies platelet protein substrates.". J Biol Chem. 2017. PMID 28364042.
"Red/ox states of human protein disulfide isomerase regulate binding affinity of 17 beta-estradiol.". Arch Biochem Biophys. 2017. PMID 28257787.
"Protein disulfide isomerase externalization in endothelial cells follows classical and unconventional routes.". Free Radic Biol Med. 2017. PMID 28034831.
"Polymorphisms in protein disulfide isomerase are associated with sporadic amyotrophic lateral sclerosis in the Chinese Han population.". Int J Neurosci. 2016. PMID 26000911.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] P4HB - Cronfa NCBI

[1]

[2]