PACSIN2

PACSIN2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3ABH, 3ACO, 3HAJ, 3Q0K
Dynodwyr
Cyfenwau	PACSIN2, SDPII, protein kinase C and casein kinase substrate in neurons 2
Dynodwyr allanol	OMIM: 604960 HomoloGene: 21414 GeneCards: PACSIN2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transporter activity; • cytoskeletal protein binding; • phosphatidic acid binding; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • lipid binding; • cadherin binding; • phospholipid binding;
Cydrannau o'r gell	• endosome; • cell projection; • bilen; • intracellular membrane-bounded organelle; • cell-cell junction; • focal adhesion; • ruffle membrane; • recycling endosome membrane; • early endosome; • caveola; • extracellular exosome; • cytoplasmic vesicle membrane; • Cytosgerbwd; • GO:0016023 cytoplasmic vesicle; • extrinsic component of membrane; • cytoplasm; • cytosol; • Cellbilen; • nuclear speck; • glutamatergic synapse;
Prosesau biolegol	• regulation of endocytosis; • caveolin-mediated endocytosis; • negative regulation of endocytosis; • endocytosis; • caveola assembly; • plasma membrane tubulation; • protein localization to endosome; • cell projection morphogenesis; • actin cytoskeleton organization; • membrane organization; • cytoskeleton organization; • modulation of chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologau
	11252
	n/a
	ENSG00000100266
	n/a
	Q9UNF0
	n/a
NM_001184970; NM_001184971; NM_007229; NM_001349968; NM_001349969;
	NM_001349970; NM_001349971; NM_001349972; NM_001349973; NM_001349974
	n/a
NP_001171899; NP_001171900; NP_009160; NP_001336897; NP_001336898;
	NP_001336899; NP_001336900; NP_001336901; NP_001336902; NP_001336903
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PACSIN2 yw PACSIN2 a elwir hefyd yn Protein kinase C and casein kinase substrate in neurons 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q13.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PACSIN2.

SDPII

Llyfryddiaeth

"FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets. ". Blood. 2015. PMID 25838348.
"The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization. ". J Biol Chem. 2012. PMID 23129763.
"Tip-to-tip interaction in the crystal packing of PACSIN 2 is important in regulating tubulation activity. ". Protein Cell. 2013. PMID 23888307.
"Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent Endocytosis. ". PLoS Pathog. 2016. PMID 27942025.
"Phosphorylation of PACSIN2 by protein kinase C triggers the removal of caveolae from the plasma membrane.". J Cell Sci. 2015. PMID 26092940.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PACSIN2 - Cronfa NCBI

[1]

[2]