PAK1

PAK1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1F3M, 1YHW, 1ZSG, 2HY8, 2QME, 3DVP, 3FXZ, 3FY0, 3Q4Z, 3Q52, 3Q53, 4DAW, 4EQC, 4O0R, 4O0T, 4P90, 4ZJI, 4ZJJ, 4ZY4, 4ZY5, 4ZY6, 4ZLO, 5DFP, 5DEY, 5IME
Dynodwyr
Cyfenwau	PAK1, PAKalpha, p21 (RAC1) activated kinase 1, IDDMSSD
Dynodwyr allanol	OMIM: 602590 HomoloGene: 1936 GeneCards: PAK1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• ATP binding; • collagen binding; • GO:0001948, GO:0016582 protein binding; • kinase activity; • catalytic activity; • nucleotide binding; • transferase activity; • protein serine/threonine kinase activity; • protein kinase activity; • identical protein binding; • protein kinase binding;
Cydrannau o'r gell	• cell projection; • ruffle membrane; • bilen; • filamentous actin; • cell-cell junction; • cell junction; • focal adhesion; • cytoplasm; • intercalated disc; • dendrite; • Cellbilen; • Z discdkac; • axon; • nuclear membrane; • ruffle; • cytosol; • lamellipodium; • GO:0009327 protein-containing complex; • Microffilament; • nucleoplasm; • cnewyllyn cell; • Cromosom;
Prosesau biolegol	• positive regulation of protein phosphorylation; • cellular response to insulin stimulus; • negative regulation of cell proliferation involved in contact inhibition; • response to hypoxia; • exocytosis; • positive regulation of JUN kinase activity; • MAPK cascade; • regulation of actin cytoskeleton organization; • positive regulation of intracellular estrogen receptor signaling pathway; • branching morphogenesis of an epithelial tube; • ephrin receptor signaling pathway; • positive regulation of stress fiber assembly; • T cell costimulation; • wound healing; • positive regulation of cell migration; • GO:0097285 apoptotic process; • Fc-gamma receptor signaling pathway involved in phagocytosis; • Fc-epsilon receptor signaling pathway; • phosphorylation; • metabolaeth; • stimulatory C-type lectin receptor signaling pathway; • response to organic substance; • T cell receptor signaling pathway; • neuron projection morphogenesis; • positive regulation of cell population proliferation; • protein autophosphorylation; • actin cytoskeleton reorganization; • protein phosphorylation; • Rho protein signal transduction; • regulation of mitotic cell cycle; • positive regulation of fibroblast migration; • cerebellum development; • establishment of cell polarity; • positive regulation of microtubule polymerization; • activation of protein kinase activity; • positive regulation of peptidyl-serine phosphorylation; • regulation of apoptotic process; • positive regulation of axon extension; • hepatocyte growth factor receptor signaling pathway; • regulation of axonogenesis; • negative regulation of cell growth involved in cardiac muscle cell development; • positive regulation of protein targeting to membrane; • positive regulation of vascular associated smooth muscle cell proliferation; • positive regulation of vascular associated smooth muscle cell migration; • GO:0072468 signal transduction; • stress-activated protein kinase signaling cascade; • regulation of MAPK cascade; • GO:1903106 positive regulation of insulin receptor signaling pathway; • cellular response to DNA damage stimulus; • cell migration; • chromatin remodeling;
	Sources:Amigo / QuickGO
Orthologau
	5058
	n/a
	ENSG00000149269
	n/a
	Q13153
	n/a
	NM_001128620; NM_002576
	n/a
NP_001122092; NP_002567; NP_001363197; NP_001363198; NP_001363199;
	NP_001363200; NP_001363201; NP_001363202; NP_001363203; NP_001363204; NP_001363205; NP_001363206; NP_001363207; NP_001363208; NP_001363209; NP_001363210; NP_001363211; NP_001363212; NP_001363213; NP_001363214; NP_001363215; NP_001363216; NP_001363217; NP_001363218; NP_001363219; NP_001363220; NP_001363221; NP_001363222; NP_001363223; NP_001363224; NP_001363230; NP_001363231; NP_001363232; NP_001363233; NP_001363234
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PAK1 yw PAK1 a elwir hefyd yn Serine/threonine-protein kinase PAK 1 a P21 (RAC1) activated kinase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q13.5-q14.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PAK1.

PAKalpha

Llyfryddiaeth

"Old drug new tricks: Chlorhexidine acts as a potential allosteric inhibitor toward PAK1. ". Biochem Biophys Res Commun. 2018. PMID 29146188.
"Targeting PAK1. ". Biochem Soc Trans. 2017. PMID 28202661.
"Clinicopathological signature of p21-activated kinase 1 in prostate cancer and its regulation of proliferation and autophagy via the mTOR signaling pathway. ". Oncotarget. 2017. PMID 28186966.
"P21-activated kinase 1 regulates resistance to BRAF inhibition in human cancer cells. ". Mol Carcinog. 2017. PMID 28052407.
"Up-regulation of stem cell markers by P21-activated kinase 1 contributes to 5-fluorouracil resistance of colorectal cancer.". Cancer Biol Ther. 2016. PMID 27260988.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PAK1 - Cronfa NCBI

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[2]